The applicant points out that myocardial dysfunction associated with coronary artery disease may be due to infarction, viable but stunned or viable but hibernating myocardium. The applicant seeks to determine whether hibernating myocardium that is not treated with revascularization will result in progressive myocardial cell death and fibrosis, resulting in worsening heart failure. He describes the pig model of hibernation developed in his laboratory in which a chronic partial stenosis is placed on the coronary artery of a pig. The hypotheses are: 1. That myocyte cell death and fibrosis worsen as the duration of hibernation is prolonged, 2) that frequent episodes of demand ischemia will worsen the outcome; and 3) that beta blockers will attenuate the phenomenon. Daily dobutamine infusions will be used to try to exacerbate the progression of cell death and fibrosis. Beta blockers will be used to ameliorate the proposed worsening. It is hoped that this study will provide strategies for treating ischemic cardiomyopathy and end-stage heart failure.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL063688-02
Application #
6184446
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1999-04-01
Project End
2002-03-31
Budget Start
2000-05-01
Budget End
2001-03-31
Support Year
2
Fiscal Year
2000
Total Cost
$149,167
Indirect Cost
Name
Newark Beth Israel Medical Center
Department
Type
DUNS #
City
Newark
State
NJ
Country
United States
Zip Code
07112