This program is a continuation of an ongoing collaboration between investigators at Massachusetts General Hospital, King's College, and Massachusetts Institute of Technology. The long term objective of this work is to develop a new method of high resolution intravascular imaging to overcome current limitations in cardiac diagnostics, principally the identification of coronary lesions likely to undergo rupture. Most myocardial infarctions (MIs) result from the rupture of small rather than large plaques in the coronary arteries. These plaques contain a relatively large amount of lipid and have thin intimal caps. When these plaques rupture, they release thrombogenic material into the blood, clot forms, and the vessel occludes. These small plaques are beyond the detection limit of any currently available imaging modality. Therefore, a true clinical need exists for an imaging technology capable of identifying these lesions prior to rupture. Optical coherence tomography (OCT), a new method of high resolution imaging, has demonstrated great potential for the assessment of high-risk plaque. OCT is analogous to ultrasound, measuring the intensity of infrared light rather than sound. Its resolution is currently up to 25X higher than high frequency ultrasound (30MHz), the current clinical technology with the highest resolution. Advantages of OCT, in addition to its resolution, are its compact portable design, small catheter diameter, and near real time imaging rate. The general hypothesis of this work is that several advances could substantially improve the ability of OCT to characterize unstable plaque and improve patient risk stratification. These advances include improving penetration, combining OCT with spectroscopy, and processing data for superior interpretation.
Each specific aim will address an independent hypothesis that improves the diagnostic capabilities of OCT.
The specific aims are:
(Aim 1) To Increasing the Penetration through Blood with Index Matching, (Aim 2) To Characterize Tissue with Absorption and Polarization Spectroscopy, (Aim 3) To Reduce Multiple Scattering with Ultrasound, and (Aim 4) To Improve Data Interpretation through Image Processing.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL063953-03
Application #
6499036
Study Section
Special Emphasis Panel (ZRG1-DMG (04))
Program Officer
Dunn, Rosalie
Project Start
2000-02-03
Project End
2004-01-31
Budget Start
2002-02-01
Budget End
2003-01-31
Support Year
3
Fiscal Year
2002
Total Cost
$311,063
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Liu, Bin; Azimi, Ehsan; Brezinski, Mark E (2010) Improvement in dynamic range limitation of swept source optical coherence tomography by true logarithmic amplification. J Opt Soc Am A Opt Image Sci Vis 27:404-14
Azimi, Ehsan; Liu, Bin; Brezinski, Mark E (2010) Real-time and high-performance calibration method for high-speed swept-source optical coherence tomography. J Biomed Opt 15:016005
Huang, Chuanyong; Liu, Bin; Brezinski, Mark E (2008) Ultrasound-enhanced optical coherence tomography: improved penetration and resolution. J Opt Soc Am A Opt Image Sci Vis 25:938-46
Giattina, Susanne D; Courtney, Brian K; Herz, Paul R et al. (2006) Assessment of coronary plaque collagen with polarization sensitive optical coherence tomography (PS-OCT). Int J Cardiol 107:400-9
Stamper, Debra; Weissman, Neil J; Brezinski, Mark (2006) Plaque characterization with optical coherence tomography. J Am Coll Cardiol 47:C69-79
Adams Jr, Samuel B; Herz, Paul R; Stamper, Debra L et al. (2006) High-resolution imaging of progressive articular cartilage degeneration. J Orthop Res 24:708-15
Rogowska, J; Patel, N; Plummer, S et al. (2006) Quantitative optical coherence tomographic elastography: method for assessing arterial mechanical properties. Br J Radiol 79:707-11
Brezinski, Mark E (2006) Optical coherence tomography for identifying unstable coronary plaque. Int J Cardiol 107:154-65
Patel, Nirlep A; Li, Xingde; Stamper, Debra L et al. (2005) Using optical coherence tomography to guide articular cartilage ablation. Am J Orthop 34:111-5
Patel, Nirlep A; Zoeller, Jason; Stamper, Debra L et al. (2005) Monitoring osteoarthritis in the rat model using optical coherence tomography. IEEE Trans Med Imaging 24:155-9

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