Abstract

The researchers will 1) demonstrate the altered epithelial integrity associated with preeclampsia that is characterized by diminished barrier function and increase intracellular permeability; 2) determine how placenta-derived factors mediate the epithelial barrier dysfunction of preeclampsia; and 3) identify the cellular mediators that are responsible for the altered endothelial integrity mediated by placental factors in preeclampsia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL065997-03
Application #
6617921
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Barouch, Winifred
Project Start
2001-08-24
Project End
2005-07-31
Budget Start
2003-08-01
Budget End
2004-07-31
Support Year
3
Fiscal Year
2003
Total Cost
$217,500
Indirect Cost

  Institution

Name
Louisiana State University Hsc Shreveport
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
095439774
City
Shreveport
State
LA
Country
United States
Zip Code
71103

  Publications

Wang, Yuping; Dong, Qin; Gu, Yang et al. (2016) Up-regulation of miR-203 expression induces endothelial inflammatory response: Potential role in preeclampsia. Am J Reprod Immunol 76:482-490
Ma, Rong; Gu, Baihan; Gu, Yang et al. (2014) Down-regulation of TIMP3 leads to increase in TACE expression and TNF? production by placental trophoblast cells. Am J Reprod Immunol 71:427-33
Sun, J; Zhong, W; Gu, Y et al. (2014) 1,25(OH)2D3 suppresses COX-2 up-regulation and thromboxane production in placental trophoblast cells in response to hypoxic stimulation. Placenta 35:143-5
Zhong, Weijie; Gu, Baihan; Gu, Yang et al. (2014) Activation of vitamin D receptor promotes VEGF and CuZn-SOD expression in endothelial cells. J Steroid Biochem Mol Biol 140:56-62
Gu, Yang; Sun, Jingxia; Groome, Lynn J et al. (2013) Differential miRNA expression profiles between the first and third trimester human placentas. Am J Physiol Endocrinol Metab 304:E836-43
Wang, Yuping; Alexander, J Steven (2013) Role of chymase in preeclampsia. Curr Vasc Pharmacol 11:606-15
Wang, Yuping; Fan, Ruping; Gu, Yang et al. (2012) Digoxin immune fab protects endothelial cells from ouabain-induced barrier injury. Am J Reprod Immunol 67:66-72
Gu, Y; Groome, L J; Alexander, J S et al. (2012) PAR-2 triggers placenta-derived protease-induced altered VE-cadherin reorganization at endothelial junctions in preeclampsia. Placenta 33:803-9
Ma, Rong; Gu, Yang; Zhao, Shuang et al. (2012) Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am J Physiol Endocrinol Metab 303:E928-35
Alexander, Jonathan Steven; Wang, Yuping (2012) Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: 'antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability' Hypertens Res 35:892-3

Showing the most recent 10 out of 52 publications