Patients with chest pain suffer from inadequate blood supply to the heart. This """"""""myocardial ischemia"""""""" is reflected in changes in many physiologic parameters, including coronary flow reserve and myocardial contractile reserve. Perfusion imaging and stress-induced wall motion are the most commonly used clinical tests for ischemia assessment. Unfortunately these current clinical standards are known to have significant inaccuracy due to fundamental issues of image resolution and image quality. Improving the clinical assessment of myocardial ischemia will be enormously important since there are more than 3 million studies are conducted each year. Magnetic resonance imaging is potentially able to overcome all the known technical difficulties associated with the current techniques. While raw image acquisition speed has improved significantly, the goal of assessing myocardial contraction and perfusion volumetrically during an induced 60-90 second time window of true ischemia is far from being realized. This is primarily limited by inadequate imaging speed. It is also hindered by the inability to adjust, in real-time, the scan volume during the course of the study. In this proposal, we will develop an integrated examination of cardiac ischemia that will allow for real-time interactive evaluation of myocardial contraction and perfusion at 24 true frames/second/slice over at least 3 slices. It is expected that this research will have a significant impact on the accuracy of clinical ischemia assessment.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL067161-01A2
Application #
6578675
Study Section
Diagnostic Radiology Study Section (RNM)
Program Officer
Buxton, Denis B
Project Start
2003-02-10
Project End
2007-01-31
Budget Start
2003-02-10
Budget End
2004-01-31
Support Year
1
Fiscal Year
2003
Total Cost
$380,023
Indirect Cost
Name
Stanford University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Sümbül, Uygar; Santos, Juan M; Pauly, John M (2009) A practical acceleration algorithm for real-time imaging. IEEE Trans Med Imaging 28:2042-51
Sümbül, Uygar; Santos, Juan M; Pauly, John M (2009) Improved time series reconstruction for dynamic magnetic resonance imaging. IEEE Trans Med Imaging 28:1093-104
Lustig, Michael; Kim, Seung-Jean; Pauly, John M (2008) A fast method for designing time-optimal gradient waveforms for arbitrary k-space trajectories. IEEE Trans Med Imaging 27:866-73
Cukur, Tolga; Santos, Juan M; Nishimura, Dwight G et al. (2008) Varying kernel-extent gridding reconstruction for undersampled variable-density spirals. Magn Reson Med 59:196-201
Lustig, Michael; Donoho, David; Pauly, John M (2007) Sparse MRI: The application of compressed sensing for rapid MR imaging. Magn Reson Med 58:1182-95
Santos, Juan M; Cunningham, Charles H; Lustig, Michael et al. (2006) Single breath-hold whole-heart MRA using variable-density spirals at 3T. Magn Reson Med 55:371-9
Nayak, Krishna S; Hargreaves, Brian A; Hu, Bob S et al. (2005) Spiral balanced steady-state free precession cardiac imaging. Magn Reson Med 53:1468-73
Cunningham, Charles H; Arai, Takayasu; Yang, Phillip C et al. (2005) Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magn Reson Med 53:999-1005
DiCarlo, Julie C; Hargreaves, Brian A; Nayak, Krishna S et al. (2005) Variable-density one-shot Fourier velocity encoding. Magn Reson Med 54:645-55
Beatty, Philip J; Nishimura, Dwight G; Pauly, John M (2005) Rapid gridding reconstruction with a minimal oversampling ratio. IEEE Trans Med Imaging 24:799-808

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