Continuous Positive Airway Pressure (CPAP) is the most commonly prescribed treatment for obstructive sleep apnea, but adherence is low. Previous efforts to enhance adherence to CPAP treatment yielded modest improvements, and were not theory driven. Motivational Enhancement (ME) is a theory driven treatment that has been used successfully to improve treatment adherence in other medical conditions. The primary aim of this study is to compare the efficacy of ME and an education intervention (ED) to standard clinical care (SC) for improving adherence to CPAP in patients with moderate to severe OSA.
A second aim i s to examine the relationship between the amount of CPAP use and changes in cognition, mood, self-reports of daytime sleepiness and sleep-related functional status. Three hundred participants (30-80 years of age) diagnosed with sleep apnea will use CPAP for 1 week and will then be randomized to 1 of 3 conditions. The SC group will receive only the usual clinical care from the sleep center, the ME and ED group will receive two 45-minute individual treatment sessions after 1 week and 2 weeks of CPAP use. The ME intervention will provide each participant with physiological feedback of their sleep and cognitive functioning, and incorporate techniques specifically aimed at enhancing motivation to adhere to treatment. The ED group will receive the same amount of individualized attention, but will only be instructed on the patho-physiology of and correlates of OSA and benefits of treatment. CPAP adherence will be monitored covertly by data recorded in the CPAP units after 2 weeks, 3, 6 and 12 months. Follow up assessments of cognition, mood, daytime sleepiness and sleep-related functional status will be conducted at 3,6 and 12 months post treatment.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL067209-01
Application #
6321751
Study Section
Special Emphasis Panel (ZRG1-RPHB-2 (01))
Program Officer
Twery, Michael
Project Start
2001-04-01
Project End
2005-02-28
Budget Start
2001-04-01
Budget End
2002-02-28
Support Year
1
Fiscal Year
2001
Total Cost
$461,404
Indirect Cost
Name
Brown University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Hilsendager, Chelsea A; Zhang, Duan; McRae, Cynthia et al. (2016) Assessing the influence of obesity on longitudinal executive functioning performance in patients with obstructive sleep apnea syndrome. Obes Res Clin Pract 10:33-40
Hoth, Karin F; Zimmerman, Molly E; Meschede, Kimberly A et al. (2013) Obstructive sleep apnea: impact of hypoxemia on memory. Sleep Breath 17:811-7
Aloia, Mark S; Arnedt, J Todd; Strand, Matthew et al. (2013) Motivational enhancement to improve adherence to positive airway pressure in patients with obstructive sleep apnea: a randomized controlled trial. Sleep 36:1655-62
Aloia, Mark S; Knoepke, Christopher E; Lee-Chiong, Teofilo (2010) The new local coverage determination criteria for adherence to positive airway pressure treatment: testing the limits? Chest 138:875-9
Aloia, Mark S; Goodwin, Matthew S; Velicer, Wayne F et al. (2008) Time series analysis of treatment adherence patterns in individuals with obstructive sleep apnea. Ann Behav Med 36:44-53
Felver-Gant, Joshua C; Bruce, Amanda S; Zimmerman, Molly et al. (2007) Working memory in obstructive sleep apnea: construct validity and treatment effects. J Clin Sleep Med 3:589-94
Aloia, Mark S; Smith, Kevin; Arnedt, J Todd et al. (2007) Brief behavioral therapies reduce early positive airway pressure discontinuation rates in sleep apnea syndrome: preliminary findings. Behav Sleep Med 5:89-104
Zimmerman, Molly E; Arnedt, J Todd; Stanchina, Michael et al. (2006) Normalization of memory performance and positive airway pressure adherence in memory-impaired patients with obstructive sleep apnea. Chest 130:1772-8
Aloia, Mark S; Arnedt, J Todd; Stepnowsky, Carl et al. (2005) Predicting treatment adherence in obstructive sleep apnea using principles of behavior change. J Clin Sleep Med 1:346-53
Aloia, Mark S; Stanchina, Michael; Arnedt, J Todd et al. (2005) Treatment adherence and outcomes in flexible vs standard continuous positive airway pressure therapy. Chest 127:2085-93

Showing the most recent 10 out of 13 publications