This proposal develops task-based methods for evaluating and optimizing acquisition, reconstruction, and processing techniques for gated myocardial perfusion SPECT. Gated SPECT yields a series of volume images of the left ventricle, each representing one portion of the cardiac cycle. Several clinical tasks may be performed with the resulting images, including visual observation of motion properties (the detection task). For example, physicians will frequently view animations to assess whether the left ventricular wall appears to move normally. However, reconstruction methods designed for gated SPECT have never been evaluated on such a task, largely due to a lack of appropriate tools. The initial phase of the research involves the development of new tools, including a realistic mathematical phantom that can model a continuum of cardiac motions and an interactive software application for presenting motion images to observers in a controlled experiment. These tools will be used in a series of human observer studies meant to emulate the clinical task of detecting abnormal cardiac motion from animated displays of gated SPECT reconstructions. The initial observer studies will focus on optimizing acquisition parameters, such as the number of gated frames and the presentation frame rate, and on determining whether accurate modeling of physical effects, like attenuation or scatter, has an effect on the detection task. Further observer studies will be used to optimize smoothing parameters for 4D reconstruction and processing methods, and compare these methods to determine if one offers improved performance in the detection task. Lastly, the research proposes to develop a set of computer-based observers, so as to reduce the need for time-consuming human observer studies in the future. The computer-based observers, will incorporate the Channelized Hotelling Observer concept, extending it to the spatiotemporal domain, and will be bases on psychophysical properties of the human visual system. Computer-based observers will be trained and evaluated on the same image detection tasks as in the human observer studies to determine the computer-based observer most likely to emulate human task performance.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL068075-02
Application #
6527792
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Buxton, Denis B
Project Start
2001-09-17
Project End
2005-07-31
Budget Start
2002-08-01
Budget End
2003-07-31
Support Year
2
Fiscal Year
2002
Total Cost
$159,690
Indirect Cost
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Lee, Taek-Soo; Tsui, Benjamin M W (2015) The development and initial evaluation of a realistic simulated SPECT dataset with simultaneous respiratory and cardiac motion for gated myocardial perfusion SPECT. Phys Med Biol 60:1399-413
Lee, Taek-Soo; Higuchi, Takahiro; Lautamäki, Riikka et al. (2015) Task-based evaluation of a 4D MAP-RBI-EM image reconstruction method for gated myocardial perfusion SPECT using a human observer study. Phys Med Biol 60:6789-809
Veress, Alexander I; Fung, George S K; Lee, Taek-Soo et al. (2015) The direct incorporation of perfusion defect information to define ischemia and infarction in a finite element model of the left ventricle. J Biomech Eng 137:051004
Lee, Taek-Soo; Frey, Eric C; Tsui, Benjamin M W (2015) Development of 4D mathematical observer models for the task-based evaluation of gated myocardial perfusion SPECT. Phys Med Biol 60:2751-63
Lee, Taek-Soo; Park, Min Jae; Tsui, Benjamin M W (2011) A Simulation Study of the Effect of Phase-Shift on Dual Gated Myocardial Perfusion ECT. IEEE Nucl Sci Symp Conf Rec (1997) 2011:2728-2732
Park, Min Jae; Chen, Si; Lee, Taek-Soo et al. (2011) Generation and Evaluation of a Simultaneous Cardiac and Respiratory Gated Rb-82 PET Simulation. IEEE Nucl Sci Symp Conf Rec (1997) 2011:3327-3330
Fung, George S K; Higuchi, Takahiro; Park, Min Jae et al. (2011) Development of a 4D Digital Phantom for Tracer Kinetic Modeling and Analysis of Dynamic Perfusion PET and SPECT Simulation Studies. IEEE Nucl Sci Symp Conf Rec (1997) 2011:4192-4195
Lee, Taek-Soo; Tsui, Benjamin M W (2010) The Evaluation of Corrective Reconstruction Method For Reduced Acquisition Time and Various Anatomies of Perfusion Defect Using Channelized Hotelling Observer for Myocardial Perfusion SPECT. IEEE Nucl Sci Symp Conf Rec (1997) 2010:3523-3526
Tang, Jing; Lee, Taek-Soo; He, Xin et al. (2010) Comparison of 3D OS-EM and 4D MAP-RBI-EM reconstruction algorithms for cardiac motion abnormality classification using a motion observer. IEEE Trans Nucl Sci 57:2571
Fung, George S K; Segars, W Paul; Lee, Taek-Soo et al. (2010) Realistic Simulation of Regional Myocardial Perfusion Defects for Cardiac SPECT Studies. IEEE Nucl Sci Symp Conf Rec (1997) 2010:3061-3064

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