This application seeks to determine the factors associated with progression of sub-clinical atherosclerosis and to evaluate the associations between the progression of sub-clinical atherosclerosis and the development of clinically manifest atherosclerosis. Changes in sub-clinical atherosclerotic disease are measured noninvasively using high resolution B-mode ultrasound and presented as changes in wall thickness (in millimeters) of the carotid artery (carotid IMT). Carotid IMT is well recognized as a measure of atherosclerotic burden. Progression of disease is hypothesized to precede the development of clinical events. The current application is also designed to be able to compare progression of carotid IMT with changes in coronary calcium score, a measure of coronary artery disease. Development of clinical atherosclerosis is evaluated by onset of clinical events (myocardial infarction, stroke, angina.) in an established cohort with a broad age-distribution and a multi-ethnic composition (MESA: Multi-Ethnic Study of Atherosclerosis). As compared to previous published works on the topic, this application offers the opportunity of measuring atherosclerosis across a broad age distribution and in a multi-ethnic cohort using state-of-the-art technologies. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL069003-03
Application #
6901126
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Ni, Hanyu
Project Start
2003-06-15
Project End
2008-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
3
Fiscal Year
2005
Total Cost
$599,673
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
079532263
City
Boston
State
MA
Country
United States
Zip Code
02111
Polak, Joseph F; Szklo, Moyses; O'Leary, Daniel H (2017) Carotid Intima-Media Thickness Score, Positive Coronary Artery Calcium Score, and Incident Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 6:
Polak, Joseph F; O'Leary, Daniel H (2016) Carotid Intima-Media Thickness as Surrogate for and Predictor of CVD. Glob Heart 11:295-312.e3
Polak, Joseph F; O'Leary, Daniel H (2015) Edge-detected common carotid artery intima-media thickness and incident coronary heart disease in the multi-ethnic study of atherosclerosis. J Am Heart Assoc 4:e001492
Polak, Joseph F; Szklo, Moyses; O'Leary, Daniel H (2015) Associations of Coronary Heart Disease with Common Carotid Artery Near and Far Wall Intima-Media Thickness: The Multi-Ethnic Study of Atherosclerosis. J Am Soc Echocardiogr 28:1114-21
Bielinski, Suzette J; Berardi, Cecilia; Decker, Paul A et al. (2015) P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 240:3-9
Polak, Joseph F; Sacco, Ralph L; Post, Wendy S et al. (2014) Incident stroke is associated with common carotid artery diameter and not common carotid artery intima-media thickness. Stroke 45:1442-6
Berardi, Cecilia; Decker, Paul A; Kirsch, Phillip S et al. (2014) Plasma and serum L-selectin and clinical and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Transl Res 163:585-92
Polak, Joseph F; Post, Wendy S; Carr, J Jeffrey et al. (2014) Associations of common carotid intima-media thickness with coronary heart disease risk factors and events vary with distance from the carotid bulb. J Am Soc Echocardiogr 27:991-7
Polak, Joseph F; Szklo, Moyses; Kronmal, Richard A et al. (2013) The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis. J Am Heart Assoc 2:e000087
Adar, Sara D; Sheppard, Lianne; Vedal, Sverre et al. (2013) Fine particulate air pollution and the progression of carotid intima-medial thickness: a prospective cohort study from the multi-ethnic study of atherosclerosis and air pollution. PLoS Med 10:e1001430

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