Vitamin K may play a role in the pathogenesis of vascular calcification, as well as age-related bone loss. Epidemiological evidence has shown associations between the vitamin K-dependent protein, Matrix Gla Protein (MGP) and vascular calcification. Biochemical markers of vitamin K nutrition have been associated with vascular calcification, in addition to low bone mass. Usual dietary intakes of vitamin K are low. However, it is not known if these markers of vitamin K nutrition are indicators of generalized poor nutritional status in these studies. Furthermore, the impact of long-term vitamin K supplementation on vascular calcification has not been examined. In an ancillary study to a funded 3-year, double-blind, placebo controlled study on the effect of vitamin K supplementation on bone mineral density (BMD) and bone turnover, we propose to study the effect of vitamin K supplementation (500 g/d) on the progression of vascular calcification in 450 men and women, aged 60-80 years, who are already being monitored for bone loss. We will measure vascular calcification using electron beam computed tomography (EBCT) at the beginning and the end of 3 years of vitamin K supplementation. In addition, we will measure serum MGP and plasma lipids at 1, 6, 12, 24, and 36 months of vitamin K supplementation. Other covariates that will be collected through the course of the study as part of the funded study, include biochemical markers of vitamin K, vitamin D and calcium, markers of bone turnover, BMD of the hip, age, anthropometric data, physical activity, dietary intakes, medication use, and smoking. The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL069272-01
Application #
6439256
Study Section
Special Emphasis Panel (ZHL1-CSR-O (S1))
Program Officer
Applebaum-Bowden, Deborah
Project Start
2001-09-30
Project End
2005-07-31
Budget Start
2001-09-30
Budget End
2002-07-31
Support Year
1
Fiscal Year
2001
Total Cost
$307,401
Indirect Cost
Name
Tufts University
Department
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02111
Shea, M Kyla; Dawson-Hughes, Bess; Gundberg, Caren M et al. (2017) Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial. J Bone Miner Res 32:243-249
Shea, M Kyla; Booth, Sarah L (2016) Concepts and Controversies in Evaluating Vitamin K Status in Population-Based Studies. Nutrients 8:
Shea, M Kyla; Booth, Sarah L; Miller, Michael E et al. (2013) Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr 98:197-208
Shea, M Kyla; O'Donnell, Christopher J; Vermeer, Cees et al. (2011) Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults. J Nutr 141:1529-34
Peter, I; Crosier, M D; Yoshida, M et al. (2011) Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis. Osteoporos Int 22:1199-209
Misra, Devyani; Booth, Sarah L; Crosier, Micheal D et al. (2011) Matrix Gla protein polymorphism, but not concentrations, is associated with radiographic hand osteoarthritis. J Rheumatol 38:1960-5
Shea, M Kyla; Booth, Sarah L; Gundberg, Caren M et al. (2010) Adulthood obesity is positively associated with adipose tissue concentrations of vitamin K and inversely associated with circulating indicators of vitamin K status in men and women. J Nutr 140:1029-34
McKeown, Nicola M; Yoshida, Makiko; Shea, M Kyla et al. (2009) Whole-grain intake and cereal fiber are associated with lower abdominal adiposity in older adults. J Nutr 139:1950-5
Crosier, Michael D; Peter, Inga; Booth, Sarah L et al. (2009) Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status. J Nutr Sci Vitaminol (Tokyo) 55:112-9
Shea, M Kyla; Gundberg, Caren M; Meigs, James B et al. (2009) Gamma-carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr 90:1230-5

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