This proposal describes a study aimed at evaluating the relation of retinal microvascular characteristics(e.g., retinal arteriolar narrowing, arterio- venous nicking, and retinopathy) to subclinical cardiovascular disease, clinical disease, and their risk factors, in the Multi-Ethnic Study of Atherosclerosis (MESA), involving 6,500 men and women aged 45-84 years of diverse ethnicities (Caucasians, African-Americans, Hispanics and Asian Americans). It extends new population based data that show retinal microvascular characteristics, as quantified from standardized retinal photography, are predictive of incident coronary heart disease in women and incident stroke in men and women, independent of blood pressure and other cardiovascular risk factors. In the current study, we propose adding retinal photography at the first follow-up of the MESA. We will grade these photographs for the presence and severity of retinal microvascular changes based on standardized protocols, including a quantitative, computer-based measurement of retinal arteriolar caliber. We propose to test new hypotheses that link retinal microvascular characteristics and arteriolar caliber to a wide array of subclinical cardiovascular measures (including left ventricular function defined from cardiac magnetic resonance imaging, peripheral arterial function defined from radial artery tonometry, and endothelial function defined from flow-mediated vasodilation of the brachial artery), clinical cardiovascular outcomes (including coronary heart disease, congestive cardiac failure and stroke), and their risk factors (including hypertension and diabetes). This ancillary study capitalizes on the structure and wealth of cardiovascular data in MESA, and will provide critical insights into the relative contribution of microvascular disease to the pathophysiology and natural history of subclinical and clinical cardiovascular disease, in representative populations of men and women of diverse ethnicities

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL069979-01
Application #
6463902
Study Section
Clinical Trials Review Committee (CLTR)
Program Officer
Olson, Jean
Project Start
2002-06-01
Project End
2006-05-31
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
1
Fiscal Year
2002
Total Cost
$640,138
Indirect Cost
Name
University of Wisconsin Madison
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Chew, Merwyn; Xie, Jing; Klein, Ronald et al. (2016) Sleep apnea and retinal signs in cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Sleep Breath 20:15-23
Fisher, Diana E; Klein, Barbara E K; Wong, Tien Y et al. (2016) Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. Ophthalmology 123:1297-308
Fisher, Diana E; Shrager, Sandi; Shea, Steven J et al. (2015) Visual Impairment in White, Chinese, Black, and Hispanic Participants from the Multi-Ethnic Study of Atherosclerosis Cohort. Ophthalmic Epidemiol 22:321-32
Klein, Ronald; Li, Xiaohui; Kuo, Jane Z et al. (2013) Associations of candidate genes to age-related macular degeneration among racial/ethnic groups in the multi-ethnic study of atherosclerosis. Am J Ophthalmol 156:1010-1020.e1
Yau, Joanne Wen Yee; Xie, Jing; Lamoureux, Ecosse et al. (2012) Retinal microvascular calibre and risk of incident diabetes: the multi-ethnic study of atherosclerosis. Diabetes Res Clin Pract 95:265-74
Fernandez, Antonio B; Wong, Tien Y; Klein, Ronald et al. (2012) Age-related macular degeneration and incident cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Ophthalmology 119:765-70
Greenstein, Max B; Myers, Chelsea E; Meuer, Stacy M et al. (2011) Prevalence and characteristics of choroidal nevi: the multi-ethnic study of atherosclerosis. Ophthalmology 118:2468-73
Kawasaki, Ryo; Cheung, Ning; Islam, F M Amirul et al. (2011) Is diabetic retinopathy related to subclinical cardiovascular disease? Ophthalmology 118:860-5
Yau, Joanne Wen Yee; Xie, Jing; Kawasaki, Ryo et al. (2011) Retinal arteriolar narrowing and subsequent development of CKD Stage 3: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 58:39-46
Ng, Ching Hui; Cheung, Ning; Wang, Jie Jin et al. (2011) Prevalence and risk factors for epiretinal membranes in a multi-ethnic United States population. Ophthalmology 118:694-9

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