Venous thromboembolism (VTE) has been estimated to be the third most common cardiovascular disorder. Frequently cited estimates of the incidence of VTE, and its associated outcomes, are based on studies conducted more than a decade ago and only in hospitalized patients. Contemporary data on the magnitude of this disorder, clinical profile of patients affected, acute and long-term outcomes, and use of different treatment strategies are needed given recent advances in diagnostic and therapeutic modalities. The goals of the proposed study are to collect population based data describing trends over time in the epidemiology of VTE including its incidence management, short and long-term recurrence rates, and mortality. The study will take place in residents of the Worcester, MA, metropolitan area, (2000 census = 477,800) and will examine changes over time in these and additional endpoints for patients with validated VTE in 1998, 2000 and 2002 with a minimum follow-up of three years. Complementing the community based surveillance of VTE, newly diagnosed cases of VTE occurring in members of the largest HMO in Central Massachusetts between 1998 and 2002 will be identified. This cohort is tracked by an outpatient computer database allowing for the systematic collection of additional data on treatment practices and outcomes occurring outside of the hospital setting. The proposed project will build on the investigators' clinical and epidemiological experience and on data collection methodologies used in the Worcester DVT study (1985-1989) and the ongoing Worcester Heart Attack Study. The medical records of Worcester area residents diagnosed with VTE and related diagnostic rubrics will be reviewed and validated according to pre-established diagnostic criteria. Records for additional hospitalizations and death certificates will be reviewed to examine trends in long-term recurrence and survival rates through 2005. The results of this study will provide much needed current reformation about the epidemiology of VTE and provide important data on current diagnostic and therapeutic strategies used in these patients. Implementation of this registry will set the stage for systematic long-term surveillance of this medically important Problem. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL070283-03
Application #
6868964
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Hasan, Ahmed AK
Project Start
2003-04-01
Project End
2007-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
3
Fiscal Year
2005
Total Cost
$652,300
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Huang, Wei; Goldberg, Robert J; Anderson, Frederick A et al. (2016) Occurrence and predictors of recurrence after a first episode of acute venous thromboembolism: population-based Worcester Venous Thromboembolism Study. J Thromb Thrombolysis 41:525-38
Makam, Raghavendra Charan P; Erskine, Nathaniel; McManus, David D et al. (2016) Decade-Long Trends (2001 to 2011) in the Use of Evidence-Based Medical Therapies at the Time of Hospital Discharge for Patients Surviving Acute Myocardial Infarction. Am J Cardiol 118:1792-1797
Huang, W; Goldberg, R J; Cohen, A T et al. (2015) Declining Long-term Risk of Adverse Events after First-time Community-presenting Venous Thromboembolism: The Population-based Worcester VTE Study (1999 to 2009). Thromb Res 135:1100-6
Huang, Wei; Goldberg, Robert J; Anderson, Frederick A et al. (2014) Secular trends in occurrence of acute venous thromboembolism: the Worcester VTE study (1985-2009). Am J Med 127:829-39.e5
Spencer, Frederick A; Gurwitz, Jerry H; Schulman, Sam et al. (2014) Venous thromboembolism in older adults: A community-based study. Am J Med 127:530-7.e3
Piazza, Gregory; Goldhaber, Samuel Z; Kroll, Aimee et al. (2014) Venous thromboembolism in patients with prior stroke. Clin Appl Thromb Hemost 20:43-9
Piazza, Gregory; Goldhaber, Samuel Z; Kroll, Aimee et al. (2012) Venous thromboembolism in patients with chronic obstructive pulmonary disease. Am J Med 125:1010-8
Piazza, Gregory; Goldhaber, Samuel Z; Kroll, Aimee et al. (2012) Venous thromboembolism in patients with diabetes mellitus. Am J Med 125:709-16
Spencer, Frederick A; Kroll, Aimee; Lessard, Darleen et al. (2012) Isolated calf deep vein thrombosis in the community setting: the Worcester Venous Thromboembolism study. J Thromb Thrombolysis 33:211-7
Piazza, Gregory; Goldhaber, Samuel Z; Lessard, Darleen M et al. (2011) Venous thromboembolism in heart failure: preventable deaths during and after hospitalization. Am J Med 124:252-9

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