This protocol will develop behavioral methods of preventing the health risks of long sleep. Prospective data indicate that 5 percent of population mortality is associated with long sleep (or perhaps long time-in-bed), specifically, reported sleep durations of > 7.5 hours per night. Long sleep durations are particularly prevalent in older adults, who tend to spend more time in bed, despite reduced total sleep time compared with younger adults. Moderate sleep restriction might, therefore, be one of the simplest and most effective means of prolonging life, as well as consolidating sleep. Strong support for this hypothesis can only be established with randomized long-term sleep restriction of thousands of people. Before such research can be justified, the safety and feasibility of sleep restriction in long sleepers must be demonstrated. The proposed study will examine whether older long sleepers are able to chronically restrict time-in-bed without suffering potential negative consequences. Fifty adults ages 50-70 yrs who report normally sleeping > 8.5 hrs will be examined. Following a two-week home baseline period, volunteers will be randomly assigned to two 8-week home treatments. A sleep restriction group (n=30) will follow a fixed sleep schedule in which time-in-bed is restricted precisely 90 min below each subject's median baseline time-in-bed. A control group (n=20) will have no sleep restriction, but will follow a fixed sleep schedule consistent with each subject's median baseline schedule. Adherence to the protocols will be assessed by examining the number of days in which the volunteers remain in the study, as well as changes in time-in-bed and estimated sleep. Benefits and risks will be assessed by examining changes in sleepiness, depression, quality-of-life, neurobehavioral performance, glucose tolerance, and actigraphic and subjective sleep. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL071560-02S1
Application #
6942864
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Twery, Michael
Project Start
2003-09-01
Project End
2006-06-30
Budget Start
2004-08-01
Budget End
2005-06-30
Support Year
2
Fiscal Year
2004
Total Cost
$40,740
Indirect Cost
Name
University of South Carolina at Columbia
Department
Other Health Professions
Type
Schools of Public Health
DUNS #
111310249
City
Columbia
State
SC
Country
United States
Zip Code
29208
Youngstedt, Shawn D; Kline, Christopher E; Elliott, Jeffrey A et al. (2016) Circadian Phase-Shifting Effects of Bright Light, Exercise, and Bright Light + Exercise. J Circadian Rhythms 14:2
Zielinski, Mark R; Davis, J Mark; Fadel, James R et al. (2013) Influence of chronic moderate sleep restriction and exercise training on anxiety, spatial memory, and associated neurobiological measures in mice. Behav Brain Res 250:74-80
Zielinski, Mark R; Davis, J Mark; Fadel, James R et al. (2012) Influence of chronic moderate sleep restriction and exercise on inflammation and carcinogenesis in mice. Brain Behav Immun 26:672-9
Kline, Christopher E; Zielinski, Mark R; Devlin, Tina M et al. (2010) Self-reported long sleep in older adults is closely related to objective time in bed. Sleep Biol Rhythms 8:42-51
Youngstedt, Shawn D; Kripke, Daniel F; Kline, Christopher E et al. (2010) Lack of impairment in glucose tolerance: support for further investigation of sleep restriction in older long sleepers. J Sleep Res 19:116-7
Kline, Christopher E; Durstine, J Larry; Davis, J Mark et al. (2010) Circadian rhythms of psychomotor vigilance, mood, and sleepiness in the ultra-short sleep/wake protocol. Chronobiol Int 27:161-80
Youngstedt, Shawn D (2010) Comparison of Anxiolytic Effects of Acute Exercise in Older Versus Younger Adults. J Appl Gerontol 29:251-260
Youngstedt, Shawn D; Kline, Christopher E; Zielinski, Mark R et al. (2009) Tolerance of chronic 90-minute time-in-bed restriction in older long sleepers. Sleep 32:1467-79
Zielinski, Mark R; Kline, Christopher E; Kripke, Daniel F et al. (2008) No effect of 8-week time in bed restriction on glucose tolerance in older long sleepers. J Sleep Res 17:412-9
Kline, Christopher E; Durstine, J Larry; Davis, J Mark et al. (2007) Circadian variation in swim performance. J Appl Physiol 102:641-9

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