Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL072351-02
Application #
6779108
Study Section
Special Emphasis Panel (ZHL1-CSR-J (M2))
Program Officer
Thomas, John
Project Start
2003-07-01
Project End
2007-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
2
Fiscal Year
2004
Total Cost
$362,500
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Biochemistry
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Jackson, Laurence H; Vlachodimitropoulou, Evangelia; Shangaris, Panicos et al. (2017) Non-invasive MRI biomarkers for the early assessment of iron overload in a humanized mouse model of ?-thalassemia. Sci Rep 7:43439
Huo, Yongliang; Lockhart, Jonathan R; Liu, Shanrun et al. (2017) Allogeneic bone marrow transplant in the absence of cytoreductive conditioning rescues mice with ?-thalassemia major. Blood Adv 1:2421-2432
Liu, Shanrun; McConnell, Sean C; Ryan, Thomas M (2013) Erythropoiesis in the absence of adult hemoglobin. Mol Cell Biol 33:2241-51
McConnell, Sean C; Huo, Yongliang; Liu, Shanrun et al. (2011) Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development. Mol Cell Biol 31:876-83
Huo, Yongliang; McConnell, Sean C; Liu, Shanrun et al. (2010) Humanized mouse models of Cooley's anemia: correct fetal-to-adult hemoglobin switching, disease onset, and disease pathology. Ann N Y Acad Sci 1202:45-51
Huo, Yongliang; McConnell, Sean C; Liu, Shan-Run et al. (2009) Humanized Mouse Model of Cooley's Anemia. J Biol Chem 284:4889-96
Huo, Yongliang; McConnell, Sean C; Ryan, Thomas M (2009) Preclinical transfusion-dependent humanized mouse model of beta thalassemia major. Blood 113:4763-70