The goal of this revised 4-year proposal is to link adult cardiac structure and hemodynamic function with long-term serial childhood data for body size, body composition and blood pressure. To address this goal, 685 adult white active participants in the Fels Longitudinal Study, 352 men and 333 women 20 to 70 years of age, will be studied. These adults were selected based on the availability of serial body size data from 2 to 18 years and serial body composition data from 8 to 18 years. Echo cardiographic data for cardiac structure and hemodynamic parameters will be collected from these 685 adults using well defined procedures with a well-established quality control and assurance program. The availability of the long-term childhood records of these Fels participants for body size and composition provides a unique opportunity to relate childhood data to subsequent adult data for cardiac structure and blood pressure. The innovative longitudinal statistical analysis used will include covariates such as age, gender, birth year for secular trend, adulthood lifestyle (smoking, alcohol consumption, and physical activity), adult body size and composition, menopause, and medical condition and medication use. The analysis of the hypotheses in this proposed work links cardiac structure and hemodynamic parameters in adulthood to childhood growth and body composition. Such linkages will reveal how various growth and body composition profiles and patterns during childhood can lead either to pathological or to healthy cardiac structure and hemodynamic parameters in adulthood. Understanding adult cardiac outcomes in response to changes in fat and fat-free mass from childhood into adulthood will provide important clues about potential physiologic mechanisms underlying the observed changes in BMI. Elucidating adverse relationships through such a linkage can lead to the early identification of children at high risk for adult cardiovascular disease. This investigation will relate direct measures of body composition to adult cardiac structure and hemodynamic parameters.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL072838-02
Application #
6845256
Study Section
Special Emphasis Panel (ZRG1-SNEM-5 (02))
Program Officer
Myerson, Merle
Project Start
2004-01-16
Project End
2007-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
2
Fiscal Year
2005
Total Cost
$631,816
Indirect Cost
Name
Wright State University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
047814256
City
Dayton
State
OH
Country
United States
Zip Code
45435
Lu, Juan; Shin, Yongyun; Yen, Miao-Shan et al. (2016) Peak Bone Mass and Patterns of Change in Total Bone Mineral Density and Bone Mineral Contents From Childhood Into Young Adulthood. J Clin Densitom 19:180-91
Sun, Shumei S; Sima, Adam P; Himes, John H (2014) Retarded tempo of physiological development in childhood delays the onset of the metabolic syndrome in adulthood. Ann Nutr Metab 65:175-83
Sabo, Roy T; Yen, Miao-Shan; Daniels, Stephen et al. (2014) Associations between childhood body size, composition, blood pressure and adult cardiac structure: the Fels Longitudinal Study. PLoS One 9:e106333
Sabo, Roy T; Ren, Chungfeng; Sun, Shumei S (2012) Comparing Height-Adjusted Waist Circumference Indices: The Fels Longitudinal Study. Open J Endocr Metab Dis 2:40-48
Sun, S S; Sabo, Roy; Arslanian, S et al. (2012) Age variation and sexual dimorphism in the sixteen diagnostic clusters of risk factors for the metabolic syndrome. Z Gesundh Wiss 20:487-497
Chumlea, Wm C; Choh, A; Lee, M et al. (2012) MAINTAINING FUNCTION WITH AGING WHAT WE HAVE LEARNED FROM THE FELS LONGITUDINAL STUDY. J Frailty Aging 1:50-51
Wan, Wen; Deng, Xiaoyan; Archer, Kellie J et al. (2012) Pubertal pathways and the relationship to anthropometric changes in childhood: The Fels longitudinal study. Open J Pediatr 2:
Sun, Shumei S; Deng, Xiaoyan; Sabo, Roy et al. (2012) Secular trends in body composition for children and young adults: the Fels Longitudinal Study. Am J Hum Biol 24:506-14
Sabo, Roy T; Lu, Zheng; Daniels, Steven et al. (2012) Serial childhood BMI and associations with adult hypertension and obesity: the Fels Longitudinal Study. Obesity (Silver Spring) 20:1741-3
Sabo, Roy Travis; Lu, Zheng; Daniels, Stephen et al. (2010) Relationships between serial childhood adiposity measures and adult blood pressure: The Fels longitudinal study. Am J Hum Biol 22:830-5

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