Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL074724-02
Application #
6964334
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2004-09-01
Project End
2007-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2004
Total Cost
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Horne, Benjamin D; Lenzini, Petra A; Wadelius, Mia et al. (2012) Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy. Thromb Haemost 107:232-40
Lenzini, P; Wadelius, M; Kimmel, S et al. (2010) Integration of genetic, clinical, and INR data to refine warfarin dosing. Clin Pharmacol Ther 87:572-8
Voora, D; Koboldt, D C; King, C R et al. (2010) A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans. Clin Pharmacol Ther 87:445-51
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Limdi, Nita A; Wadelius, Mia; Cavallari, Larisa et al. (2010) Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups. Blood 115:3827-34
International Warfarin Pharmacogenetics Consortium; Klein, T E; Altman, R B et al. (2009) Estimation of the warfarin dose with clinical and pharmacogenetic data. N Engl J Med 360:753-64
Linder, Mark W; Bon Homme, Marjorie; Reynolds, Kristen K et al. (2009) Interactive modeling for ongoing utility of pharmacogenetic diagnostic testing: application for warfarin therapy. Clin Chem 55:1861-8
Gage, B F; Eby, C; Johnson, J A et al. (2008) Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther 84:326-31
King, Cristi R; Porche-Sorbet, Rhonda M; Gage, Brian F et al. (2008) Performance of commercial platforms for rapid genotyping of polymorphisms affecting warfarin dose. Am J Clin Pathol 129:876-83

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