We have recently observed a potentially protective effect of fish oil intake on the development of chronic obstructive pulmonary disease (COPD) using validated, questionnaire-based definitions of fish oil intake and COPD in the Nurses' Health Study. The primary aims of the current application are to replicate this promising finding with more precise measures of exposures and outcomes and to investigate potential molecular and genetic intermediaries in a population of 557 older, current and former smokers. The main hypotheses are: 1) dietary fish intake and n-3 PUFA levels are inversely associated with longitudinal lung function decline and CT lung density; 2) n-3 PUFA levels are inversely associated with biological intermediaries, such as leukotriene (LT)-B4, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and soluble adhesion molecules, and these intermediaries are on the causal pathway between n-3 PUFA levels and lung function decline; 3) related genes variants, such as those in genes coding for TNF-alpha, ICAM-1 and nitric oxide synthase (NOS) isoforms, identify individuals at higher risk of lung function decline. Baseline questionnaire, spirometry, and chest CT data and blood specimens have been collected for 557 participants, and one-year follow-up visits for questionnaire, spirometry and chest CT measures are currently ongoing. We propose to study the above hypotheses in this cohort of older, former and current smokers by extending follow-up for an additional four years; the total of six measures would yield adequate power to examine the important relationships between fish intake, n-3 polyunsaturated fatty acids (PUFA), inflammatory mediators, related gene variants and longitudinal lung function. Use of this existing cohort with previously collected blood samples will provide relatively cost-effective results about this potentially promising and safe therapy for COPD.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL075476-03
Application #
7033853
Study Section
Special Emphasis Panel (ZRG1-SNEM-5 (02))
Program Officer
Croxton, Thomas
Project Start
2004-04-01
Project End
2009-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
3
Fiscal Year
2006
Total Cost
$556,100
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Liu, Chia-Ying; Parikh, Megha; Bluemke, David A et al. (2018) Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study. J Magn Reson Imaging 47:262-271
Oelsner, Elizabeth C; Smith, Benjamin M; Hoffman, Eric A et al. (2018) Prognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study. Ann Am Thorac Soc 15:718-727
Bell, Griffith; Mora, Samia; Greenland, Philip et al. (2017) Association of Air Pollution Exposures With High-Density Lipoprotein Cholesterol and Particle Number: The Multi-Ethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 37:976-982
Hueper, Katja; Vogel-Claussen, Jens; Parikh, Megha A et al. (2015) Pulmonary Microvascular Blood Flow in Mild Chronic Obstructive Pulmonary Disease and Emphysema. The MESA COPD Study. Am J Respir Crit Care Med 192:570-80
Smith, Benjamin M; Hoffman, Eric A; Barr, R Graham (2015) Author's response: Airway anatomy in COPD: many dimensions to consider. Thorax 70:585
Varraso, Raphaƫlle; Chiuve, Stephanie E; Fung, Teresa T et al. (2015) Alternate Healthy Eating Index 2010 and risk of chronic obstructive pulmonary disease among US women and men: prospective study. BMJ 350:h286
Gassett, Amanda J; Sheppard, Lianne; McClelland, Robyn L et al. (2015) Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 4:e001726
Varraso, Raphaƫlle; Barr, R Graham; Willett, Walter C et al. (2015) Fish intake and risk of chronic obstructive pulmonary disease in 2 large US cohorts. Am J Clin Nutr 101:354-61
Hame, Yrjo; Angelini, Elsa D; Hoffman, Eric A et al. (2014) Adaptive quantification and longitudinal analysis of pulmonary emphysema with a hidden Markov measure field model. IEEE Trans Med Imaging 33:1527-40
Smith, Benjamin M; Hoffman, Eric A; Rabinowitz, Dan et al. (2014) Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax 69:987-96

Showing the most recent 10 out of 55 publications