IUGR leads to major neonatal morbidity and mortality. Moreover, recent birth registry studies have suggested that women bearing IUGR babies may have an elevated risk of cardiovascular disease. We propose a cohort study to test whether exposed women, with a previous IUGR baby, versus unexposed women, with a pregnancy not complicated by IUGR, will have elevations in markers of cardiovascular risk. Exposure will be defined among a geographically defined cohort as having had & singleton baby in the < 5 %tile of weight for gestational age, in the absence of pre-pregnancy diabetes., hypertension, renal disease, or hypertension in pregnancy; controls will have had a singleton in the > 20%tile. Five to nine years postpartum, women will be assessed for multiple markers of cardiovascular risk, including blood pressure, lipids, adiposity, glucose and insulin, homocysteine and folate, markers of inflammation, markers of endothelial function, markers of angiogenesis, and markers of vascular function. Data analysis will consist of ANOVA and ANCOVA analyses comparing the outcomes of cardiovascular markers among exposed and unexposed women. Our success in accomplishing these studies derives from a long track record of success of completing women's health cohort studies, and specifically, a similar study in preeclamptic women. The importance of this work is the potential identification of a group at high risk for later cardiovascular disease. The presence of risk markers at an early age, specifically an age wherein markers of cardiovascular risk are typically not measured, may allow for implementation of early preventative interventions.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-CICS (01))
Program Officer
Wei, Gina
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Public Health & Prev Medicine
Schools of Public Health
United States
Zip Code
Catov, J M; Muldoon, M F; Reis, S E et al. (2018) Preterm birth with placental evidence of malperfusion is associated with cardiovascular risk factors after pregnancy: a prospective cohort study. BJOG 125:1009-1017
Xu, Jia; Barinas-Mitchell, Emma; Kuller, Lewis H et al. (2014) Maternal hypertension after a low-birth-weight delivery differs by race/ethnicity: evidence from the National Health and Nutrition Examination Survey (NHANES) 1999-2006. PLoS One 9:e104149
McClure, Candace K; Catov, Janet M; Ness, Roberta et al. (2013) Associations between gestational weight gain and BMI, abdominal adiposity, and traditional measures of cardiometabolic risk in mothers 8 y postpartum. Am J Clin Nutr 98:1218-25
Catov, Janet M; Dodge, Rhiannon; Barinas-Mitchell, Emma et al. (2013) Prior preterm birth and maternal subclinical cardiovascular disease 4 to 12 years after pregnancy. J Womens Health (Larchmt) 22:835-43
Catov, Janet M; Lewis, Cora E; Lee, Minjae et al. (2013) Preterm birth and future maternal blood pressure, inflammation, and intimal-medial thickness: the CARDIA study. Hypertension 61:641-6
McClure, Candace K; Catov, Janet; Ness, Roberta et al. (2012) Maternal visceral adiposity by consistency of lactation. Matern Child Health J 16:316-21
McClure, Candace K; Catov, Janet M; Ness, Roberta B et al. (2012) Lactation and maternal subclinical cardiovascular disease among premenopausal women. Am J Obstet Gynecol 207:46.e1-8
McClure, Candace K; Bodnar, Lisa M; Ness, Roberta et al. (2011) Accuracy of maternal recall of gestational weight gain 4 to 12 years after delivery. Obesity (Silver Spring) 19:1047-53
Catov, Janet M; Dodge, Rhiannon; Yamal, Jose-Miguel et al. (2011) Prior preterm or small-for-gestational-age birth related to maternal metabolic syndrome. Obstet Gynecol 117:225-32
Ness, Roberta B; Grainger, David A (2008) Male reproductive proteins and reproductive outcomes. Am J Obstet Gynecol 198:620.e1-4

Showing the most recent 10 out of 11 publications