Pulmonary imaging techniques have traditionally emphasized the description of the anatomy and pathology of the lung parenchyma, airways, and vasculature. Recent developments in functional lung imaging and, in particular, hyperpolarized (HP) 3He MRI have generated interest for their ability to improve upon the results attained by these traditional techniques. The goal of this proposal is to implement the novel HP 3He MRI technique to generate physiological maps of regional parameters that describe lung function. The central hypothesis of this proposal is that HP 3He MRI maps of regional physiological parameters that describe lung function (i.e., regional ventilation, regional perfusion, perfusion efficiency index, regional alveolar partial pressure of oxygen, regional VA/Q) will more accurately detect early functional and structural changes in a diseased lung than existing imaging modalities. We will test our hypothesis by establishing the following specific aims: 1) To measure regional ventilation in healthy Yorkshire pigs and in pigs with increasing ventilation abnormality, 2) To measure the regional lung partial pressure of oxygen in healthy Yorkshire pigs and in pigs with varying regional ventilation and/or perfusion abnormality, 3) To measure the regional perfusion and the regional perfusion efficiency index in healthy Yorkshire pigs and in pigs that have been administered vasoconstrictor therapy, and 4) To obtain the regional VA/Q in healthy Yorkshire pigs and in pigs with increasing ventilation and perfusion abnormalities. This work will contribute towards the pivotal implementation of specific markers for the detection of and therapy for many pulmonary disorders. Our technique will delineate with greater accuracy the structural and functional changes associated with pulmonary diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL077241-02
Application #
6927120
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Croxton, Thomas
Project Start
2004-08-01
Project End
2008-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
2
Fiscal Year
2005
Total Cost
$396,250
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Yehya, Nadir; Xin, Yi; Oquendo, Yousi et al. (2015) Cecal ligation and puncture accelerates development of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 308:L443-51
Xin, Yi; Song, Gang; Cereda, Maurizio et al. (2015) Semiautomatic segmentation of longitudinal computed tomography images in a rat model of lung injury by surfactant depletion. J Appl Physiol (1985) 118:377-85
Siddiqui, Sarmad; Xin, Yi; Emami, Kiarash et al. (2014) Hyperpolarized (3)He diffusion MRI and histology of secreted frizzled related protein-1 (SFRP1) deficient lungs in a Murine model. Magn Reson Imaging 32:535-40
Cereda, Maurizio; Xin, Yi; Kadlecek, Stephen et al. (2014) Hyperpolarized gas diffusion MRI for the study of atelectasis and acute respiratory distress syndrome. NMR Biomed 27:1468-78
Cereda, Maurizio; Xin, Yi; Emami, Kiarash et al. (2013) Positive end-expiratory pressure increments during anesthesia in normal lung result in hysteresis and greater numbers of smaller aerated airspaces. Anesthesiology 119:1402-9
Cereda, Maurizio; Emami, Kiarash; Xin, Yi et al. (2013) Imaging the interaction of atelectasis and overdistension in surfactant-depleted lungs. Crit Care Med 41:527-35
Ishii, Masaru; Emami, Kiarash; Xin, Yi et al. (2012) Regional function-structure relationships in lungs of an elastase murine model of emphysema. J Appl Physiol 112:135-48
Emami, Kiarash; Chia, Elaine; Kadlecek, Stephen et al. (2011) Regional correlation of emphysematous changes in lung function and structure: a comparison between pulmonary function testing and hyperpolarized MRI metrics. J Appl Physiol 110:225-35
Cereda, Maurizio; Emami, Kiarash; Kadlecek, Stephen et al. (2011) Quantitative imaging of alveolar recruitment with hyperpolarized gas MRI during mechanical ventilation. J Appl Physiol 110:499-511
Emami, Kiarash; Kadlecek, Stephen J; Woodburn, John M et al. (2010) Improved technique for measurement of regional fractional ventilation by hyperpolarized 3He MRI. Magn Reson Med 63:137-50

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