Abstract

This is a revision of application 1 R01 HL079235-01. The overall goal of this project is to understand how depression leads to congestive heart failure (CHF) in older adults. Depression is known to be associated with an increased risk of coronary heart disease (CHD), and with adverse outcomes among older adults with CHD. Recent evidence suggests that depression is also associated with an increased risk of CHF, and with adverse outcomes among older adults with CHF. However, the mechanisms by which depression leads to CHF are not known. To determine the mechanisms of association between depression and CHF, we will use an existing cohort of 1024 older adults (mean age 67) with CHD (including 680 with no heart failure and 344 with clinical or subclinical heart failure) who were recruited between 9/00 and 12/02 for The Heart and Soul Study."""""""" The Heart and Soul Study was originally designed to understand the mechanism of association between depression and CHD. Since patients with CHD are at high risk for CHF, this well-characterized cohort will provide a unique opportunity to examine the relation between depression and CHF. At baseline, participants completed a depression interview (Diagnostic Interview Schedule);full exercise treadmill testing with stress echocardiography;24-hour Holter monitoring for heart rate variability;24-hour urine collection for cortisol and norepinephrine;venous blood measurements for lipids, platelet reactivity, and C-reactive protein;and an extensive questionnaire. Participants have been followed annually by telephone. We will invite all participants to return for a 5-year examination, and we will follow them for an additional 3 years thereafter, to determine (a) the independent association between baseline depression and CHF, and (b) the extent to which 5-vear changes in biological and behavioral factors associated with depression explain the relation between depression and CHF. By identifying the mechanisms that explain the relation between depression and CHF, this study will enable us to target specific areas for improving the treatment of these patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL079235-04S1
Application #
7845765
Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Czajkowski, Susan
Project Start
2009-07-01
Project End
2011-06-30
Budget Start
2009-07-01
Budget End
2011-06-30
Support Year
4
Fiscal Year
2009
Total Cost
$263,810
Indirect Cost

  Institution

Name
Northern California Institute Research & Education
Department
Type
DUNS #
613338789
City
San Francisco
State
CA
Country
United States
Zip Code
94121

  Publications

Culverhouse, R C; Saccone, N L; Horton, A C et al. (2018) Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. Mol Psychiatry 23:133-142
Levis, Brooke; Benedetti, Andrea; Riehm, Kira E et al. (2018) Probability of major depression diagnostic classification using semi-structured versus fully structured diagnostic interviews. Br J Psychiatry 212:377-385
Wang, Elizabeth Y; Meyer, Craig; Graham, Glenn D et al. (2018) Evaluating Screening Tests for Depression in Post-Stroke Older Adults. J Geriatr Psychiatry Neurol 31:129-135
Park, Meyeon; Maristany, Daniela; Huang, Debbie et al. (2017) Associations of tumor necrosis factor alpha receptor type 1 with kidney function decline, cardiovascular events, and mortality risk in persons with coronary artery disease: Data from the Heart and Soul Study. Atherosclerosis 263:68-73
Sin, Nancy L; Kumar, Anupama D; Gehi, Anil K et al. (2016) Direction of Association Between Depressive Symptoms and Lifestyle Behaviors in Patients with Coronary Heart Disease: the Heart and Soul Study. Ann Behav Med 50:523-32
Ganz, Peter; Heidecker, Bettina; Hveem, Kristian et al. (2016) Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease. JAMA 315:2532-41
Park, Meyeon; Kulkarni, Ameya; Beatty, Alexis et al. (2015) Soluble endothelial cell selective adhesion molecule and cardiovascular outcomes in patients with stable coronary disease: A report from the Heart and Soul Study. Atherosclerosis 243:546-52
Beatty, Alexis L; Ku, Ivy A; Bibbins-Domingo, Kirsten et al. (2015) Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study. J Am Heart Assoc 4:
Sin, Nancy L; Yaffe, Kristine; Whooley, Mary A (2015) Depressive symptoms, cardiovascular disease severity, and functional status in older adults with coronary heart disease: the heart and soul study. J Am Geriatr Soc 63:8-15
Saha, Sandeep A; Beatty, Alexis L; Mishra, Rakesh K et al. (2015) Usefulness of an Echocardiographic Composite Cardiac Calcium Score to Predict Death in Patients With Stable Coronary Artery Disease (from the Heart and Soul Study). Am J Cardiol 116:50-8

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