Strong associations exist between cardiovascular events and increased carotid artery wall intima-media thickness (IMT) as measured non-invasively by carotid ultrasound. Carotid IMT is accepted as a surrogate marker of sub-clinical cardiovascular disease. We propose to determine the rate of progression of sub-clinical cardiovascular disease (change in IMT) over a period of 8 to 10 years. Imaging and IMT measurements of approximately 2800 to 3000 members of this cohort having had baseline IMT measurements at their 1995-98 clinic visit will be repeated in 200:5-2007. The principal aims of the project are to study the primary hypotheses that: 1. Interim exposure to traditional cardiovascular risk factors measured over 50 years is positively associated with the progression rate of carotid IMT. 2. Baseline carotid IMT and cumulative exposure to cardiovascular risk factors 20 years before the baseline visit are a better predictor of progression of sub-clinical disease after 8 to 10 years than the interim exposure to risk factors. 3. Novel risk factors such as C-reactive protein and homocysteine affect progression of carotid atherosclerosis more than traditional risk factors. This application will add a phenotypic marker of site-specific change in sub-clinical cardiovascular disease to the Framingham Study database. This complements ongoing research on the progression of sub-clinical cardiovascular disease and its associations with family history of premature cardiovascular events and genomic markers. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL081352-01
Application #
6959179
Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Ni, Hanyu
Project Start
2005-09-01
Project End
2010-05-31
Budget Start
2005-09-01
Budget End
2006-05-31
Support Year
1
Fiscal Year
2005
Total Cost
$627,252
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
079532263
City
Boston
State
MA
Country
United States
Zip Code
02111
Polak, Joseph F; Szklo, Moyses; O'Leary, Daniel H (2017) Carotid Intima-Media Thickness Score, Positive Coronary Artery Calcium Score, and Incident Coronary Heart Disease: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc 6:
Polak, Joseph F; O'Leary, Daniel H (2016) Carotid Intima-Media Thickness as Surrogate for and Predictor of CVD. Glob Heart 11:295-312.e3
Polak, Joseph F; O'Leary, Daniel H (2015) Edge-detected common carotid artery intima-media thickness and incident coronary heart disease in the multi-ethnic study of atherosclerosis. J Am Heart Assoc 4:e001492
Polak, Joseph F; Szklo, Moyses; O'Leary, Daniel H (2015) Associations of Coronary Heart Disease with Common Carotid Artery Near and Far Wall Intima-Media Thickness: The Multi-Ethnic Study of Atherosclerosis. J Am Soc Echocardiogr 28:1114-21
Bielinski, Suzette J; Berardi, Cecilia; Decker, Paul A et al. (2015) P-selectin and subclinical and clinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 240:3-9
Polak, Joseph F; Sacco, Ralph L; Post, Wendy S et al. (2014) Incident stroke is associated with common carotid artery diameter and not common carotid artery intima-media thickness. Stroke 45:1442-6
Berardi, Cecilia; Decker, Paul A; Kirsch, Phillip S et al. (2014) Plasma and serum L-selectin and clinical and subclinical cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis (MESA). Transl Res 163:585-92
Polak, Joseph F; Post, Wendy S; Carr, J Jeffrey et al. (2014) Associations of common carotid intima-media thickness with coronary heart disease risk factors and events vary with distance from the carotid bulb. J Am Soc Echocardiogr 27:991-7
Polak, Joseph F; Szklo, Moyses; Kronmal, Richard A et al. (2013) The value of carotid artery plaque and intima-media thickness for incident cardiovascular disease: the multi-ethnic study of atherosclerosis. J Am Heart Assoc 2:e000087
Adar, Sara D; Sheppard, Lianne; Vedal, Sverre et al. (2013) Fine particulate air pollution and the progression of carotid intima-medial thickness: a prospective cohort study from the multi-ethnic study of atherosclerosis and air pollution. PLoS Med 10:e1001430

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