We propose to investigate the association of pericardial fat with subclinical and clinical measures of coronary heart disease. Visceral fat is more detrimental than subcutaneous fat with regard to coronary heart disease. Pericardial fat, a novel fat depot around the heart with properties like visceral fat, may be especially detrimental due to local lipotoxicity and inflammation in coronary arteries. However, epidemiologic evidence is lacking. We hypothesize that increased amounts of pericardial fat accelerates the atherosclerotic process in coronary arteries and that pericardial fat is the primary contributor to the development of coronary heart disease among commonly assessed regional fat depots. The proposed study is an ancillary study to the Multi-Ethnic Study of Atherosclerosis (MESA). We will examine 1) the association of pericardial fat with subclinical coronary heart disease (calcified coronary plaque measured by computed tomography (CT)) at baseline, 2) the association of baseline and changes in pericardial fat with changes in calcified coronary plaque over three years, and 3) the risk of clinical coronary heart disease associated with pericardial fat in a 6 year follow-up among 6,814 white, black, Hispanic, and Asian American men and women, age 45-84. The measures of calcified coronary plaque and clinical coronary heart disease will be obtained from the existing MESA database. We will measure the volume of pericardial fat using the existing CT scans in MESA, from which calcified coronary plaque was quantified, at baseline (N=6,814) and a follow-up exam (N=6,000) three years later. The MESA cohort, with extensive longitudinal assessments of cardiovascular disease, is an ideal study population for assessing the role of pericardial fat in the development of coronary heart disease. The diversified study population will also provide ethnicity-specific information on the relationships to be examined. More importantly, the existing CT scans enable us to cost-effectively measure pericardial fat without extra burden to participants. The recent report of the NIH Obesity Research Task Force indicates that elucidation of differences in various fat depots with regard to their roles in obesity-associated diseases will further our understanding of the link between obesity and its health consequences, which may yield new targets for therapeutics to disrupt this link. Given the health impact of coronary heart disease, there is a pressing need to examine the relationship between pericardial fat and coronary heart disease. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL085323-03
Application #
7439224
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Aviles-Santa, Larissa
Project Start
2006-08-21
Project End
2010-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
3
Fiscal Year
2008
Total Cost
$343,033
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Shah, Ravi V; Anderson, Amanda; Ding, Jingzhong et al. (2017) Pericardial, But Not Hepatic, Fat by CT Is Associated With CV Outcomes and Structure: The Multi-Ethnic Study of Atherosclerosis. JACC Cardiovasc Imaging 10:1016-1027
Heckbert, Susan R; Wiggins, Kerri L; Blackshear, Chad et al. (2017) Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study. Obesity (Silver Spring) 25:1115-1121
Chu, Audrey Y; Deng, Xuan; Fisher, Virginia A et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet 49:125-130
Shah, R V; Murthy, V L; Allison, M A et al. (2016) Diet and adipose tissue distributions: The Multi-Ethnic Study of Atherosclerosis. Nutr Metab Cardiovasc Dis 26:185-93
Shah, A D; Kandula, N R; Lin, F et al. (2016) Less favorable body composition and adipokines in South Asians compared with other US ethnic groups: results from the MASALA and MESA studies. Int J Obes (Lond) 40:639-45
Shah, Ravi V; Allison, Matthew A; Lima, João A C et al. (2015) Liver fat, statin use, and incident diabetes: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 242:211-7
Shah, Ravi V; Allison, Matthew A; Lima, Joao A C et al. (2015) Liver steatosis and the risk of albuminuria: the multi-ethnic study of atherosclerosis. J Nephrol 28:577-84
Ong, Kwok-Leung; Ding, Jingzhong; McClelland, Robyn L et al. (2015) Relationship of pericardial fat with biomarkers of inflammation and hemostasis, and cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 239:386-92
Ong, Kwok-Leung; Ding, Jingzhong; McClelland, Robyn L et al. (2015) Relationship of pericardial fat with lipoprotein distribution: The Multi-Ethnic study of atherosclerosis. Atherosclerosis 241:664-70
McClain, Jill; Hsu, Fang; Brown, Elizabeth et al. (2013) Pericardial adipose tissue and coronary artery calcification in the Multi-ethnic Study of Atherosclerosis (MESA). Obesity (Silver Spring) 21:1056-63

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