Principal Investigator/Program Director (Last, first, middle): Sime, Patricia, J. RESEARCH &RELATED Other Project Information 1. * Are Human Subjects Involved? l Yes m No 1.a. If YES to Human Subjects Is the IRB review Pending? l Yes m No IRB Approval Date: Exemption Number: 1 2 3 4 5 6 Human Subject Assurance Number 0000009386 2. * Are Vertebrate Animals Used? l Yes m No 2.a. If YES to Vertebrate Animals Is the IACUC review Pending? l Yes m No IACUC Approval Date: Animal Welfare Assurance Number A329201 3. * Is proprietary/privileged information m Yes l No included in the application? 4.a.* Does this project have an actual or potential impact on m Yes l No the environment? 4.b. If yes, please explain: 4.c. If this project has an actual or potential impact on the environment, has an exemption been authorized or an environmental assessment (EA) or environmental impact statement (EIS) been performed? m Yes m No 4.d. If yes, please explain: 5.a.* Does this project involve activities outside the U.S. or m Yes l No partnership with International Collaborators? 5.b. If yes, identify countries: 5.c. Optional Explanation: 6. * Project Summary/Abstract 2458-6-sime_Project_summary-abstract0M2i2m7e.pTdyf pe: application/pdf 7. * Project Narrative 9313-Project_Narrative.pdf Mime Type: application/pdf 8. Bibliography &References Cited 3471-8-Bibliography_and_references_citMedim.pedfType: application/pdf 9. Facilities &Other Resources 449-Master_Resource_Page.pdf Mime Type: application/pdf 10. Equipment 7480-Equipment_Master_Listing.pdf Mime Type: application/pdf Tracking Number: Other Information Page 5 OMB Number: 4040-0001 Expiration Date: 04/30/2008 Principal Investigator/Program Director (Last, first, middle): Sime, Patricia, J. PROJECT SUMMARY/ABSTRACT Exposure of human beings to tobacco smoke, as well as to certain dusts and environmental pollutants, incites lung inflammation and in some cases causes cancer. New evidence indicates that chronic inflammation leads to increased susceptibility to lung cancers and to other malignancies. Furthermore, cigarette smoke is the primary cause of chronic obstructive pulmonary disease (COPD-emphysema and chronic bronchitis). Despite the fact that smoking causes lung diseases, remarkably little is known of the mechanisms whereby smoke generates inflammation and how the inflammatory responses are regulated. The fibroblast is a

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL088325-02S1
Application #
7824683
Study Section
Lung Injury, Repair, and Remodeling Study Section (LIRR)
Program Officer
Punturieri, Antonello
Project Start
2009-06-01
Project End
2010-08-31
Budget Start
2009-06-01
Budget End
2010-08-31
Support Year
2
Fiscal Year
2009
Total Cost
$20,618
Indirect Cost
Name
University of Rochester
Department
Internal Medicine/Medicine
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Thatcher, Thomas H; Williams, Marc A; Pollock, Stephen J et al. (2016) Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function. Immunology 147:41-54
Hsiao, Hsi-Min; Thatcher, Thomas H; Levy, Elizabeth P et al. (2014) Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. J Immunol 193:4980-7
Lugade, Amit A; Bogner, Paul N; Thatcher, Thomas H et al. (2014) Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection. J Immunol 192:5226-35
McMillan, David H; Woeller, Collynn F; Thatcher, Thomas H et al. (2013) Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 304:L774-81
Hsiao, Hsi-Min; Sapinoro, Ramil E; Thatcher, Thomas H et al. (2013) A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PLoS One 8:e58258
Thatcher, Thomas H; Hsiao, Hsi-Min; Pinner, Elhanan et al. (2013) Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol 305:L165-74
Kottmann, Robert Matthew; Kulkarni, Ajit A; Smolnycki, Katie A et al. (2012) Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-?. Am J Respir Crit Care Med 186:740-51
Kottmann, Robert Matthew; Kelly, Jennifer; Lyda, Elizabeth et al. (2011) Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients. Thorax 66:823
Rico de Souza, Angela; Zago, Michela; Pollock, Stephen J et al. (2011) Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis. J Biol Chem 286:43214-28
Blumberg, Neil; Sime, Patricia J; Phipps, Richard P (2011) The mystery of transfusion-related acute lung injury. Transfusion 51:2054-7

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