Obesity contributes to cardiovascular disease, type 2 diabetes, liver disease and increases risk for many other serious health conditions throughout life. Over the past 3 decades, obesity rates have risen dramatically accompanied by significant health disparities. In the U.S., lower-income and minority groups are at greatest risk. Since the determinants of obesity are multifactorial, multidisciplinary research is essential to consider biological, behavioral, and social determinants and their interactions. The proposed project continues to be one of the most comprehensive longitudinal studies of risk for, and consequences of, obesity, with data on growth, social circumstances, psychological functioning, sleep and physical health from infancy to adulthood. It will involve 1100 Chileans at 22 y who participated in research related to nutrition, growth and development as infants, with follow up at 5, 10, and 16 y (with adolescent data on eating behavior, fat mass, and cardiovascular risk). Participants were born during a dramatic nutritional transition, resulting in obesity prevalence rising twice as fast as it did in the U.S. At 16 y, 37.7% were over-weight or obese, with 6% in the extreme obesity range. The continuation focuses on a sensitive period for obesity, the transition to adulthood. We will determine how the following processes influence the development of obesity and related health risks: biological and social factors in infancy and childhood (Aim 1); development of health behaviors (sleep, physical activity and eating behavior) from adolescence to young adulthood (Aim 2); and mechanisms relating sleep to obesity (Aim 3).
For Aim 1, we will continue our ongoing approach to understanding how early life factors (e.g., infancy weight gain, breastfeeding, parent characteristics, and social circumstance) relate to obesity and health risks. We expect that risks from early life will be modified by educational trajectories, work experience, and social relationships during the transition to adulthood.
For Aim 2, we will assess continuity and change in health behaviors and how they relate to obesity, cardiovascular and metabolic risk.
For Aim 3, we continue our research on the biological mechanisms relating sleep to obesity, with polysomnographic recordings in 40 overweight/obese young adults and 40 normal weight controls. Because of the study's longitudinal nature, we are positioned to unravel important questions about the direction of effects between sleep and obesity. We will also study biological and behavioral responses to sleep restriction in another subset of obese and normal weight participants (n = 80). We will assess hormonal responses, followed by 4 days of monitoring for physical activity, eating behavior and sleep. Our study is exceptional in the depth and breadth of longitudinal data from infancy to the transition to adulthood, with objective data on health behaviors in adolescence and adulthood. The study remains at the forefront of understanding the complex interactions between biology, social factors, and health behaviors as they relate to fat mass and risk for heart disease, insulin resistance, and liver disease.

Public Health Relevance

Obesity, one of the foremost public health problems in the world, leads to heart disease, diabetes, some cancers and other diseases. This research investigates how biological factors and social conditions influence the development of sleep and physical activity patterns, eating behaviors and ultimately obesity. This study will assess such effects in a sample of over 1100 young adults.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL088530-08
Application #
9081646
Study Section
Kidney, Nutrition, Obesity and Diabetes (KNOD)
Program Officer
Aviles-Santa, Larissa
Project Start
2007-04-01
Project End
2018-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
8
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pediatrics
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wu, Victoria; East, Patricia; Delker, Erin et al. (2018) Associations Among Mothers' Depression, Emotional and Learning-Material Support to Their Child, and Children's Cognitive Functioning: A 16-Year Longitudinal Study. Child Dev :
Reyes, M; Burrows, R; Blanco, E et al. (2018) Greater early weight gain and shorter breastfeeding are associated with low adolescent adiponectin levels. Pediatr Obes 13:277-284
Madewell, Zachary J; Blanco, Estela; Burrows, Raquel et al. (2018) Changes in socio-economic status and lipoproteins in Chilean adolescents: a 16-year longitudinal study. Public Health Nutr :1-10
Doom, Jenalee R; Richards, Blair; Caballero, Gabriela et al. (2018) Infant Iron Deficiency and Iron Supplementation Predict Adolescent Internalizing, Externalizing, and Social Problems. J Pediatr 195:199-205.e2
East, Patricia; Delker, Erin; Lozoff, Betsy et al. (2018) Associations Among Infant Iron Deficiency, Childhood Emotion and Attention Regulation, and Adolescent Problem Behaviors. Child Dev 89:593-608
Correa-Burrows, Paulina; Rodríguez, Yanina; Blanco, Estela et al. (2017) Snacking Quality Is Associated with Secondary School Academic Achievement and the Intention to Enroll in Higher Education: A Cross-Sectional Study in Adolescents from Santiago, Chile. Nutrients 9:
Martinez, Suzanna M; Rhee, Kyung E; Blanco, Estela et al. (2017) Latino mothers' beliefs about child weight and family health. Public Health Nutr 20:1099-1106
Pacheco, Lorena Sonia; Blanco, Estela; Burrows, Raquel et al. (2017) Early Onset Obesity and Risk of Metabolic Syndrome Among Chilean Adolescents. Prev Chronic Dis 14:E93
Burrows, R; Correa-Burrows, P; Reyes, M et al. (2017) Low muscle mass is associated with cardiometabolic risk regardless of nutritional status in adolescents: A cross-sectional study in a Chilean birth cohort. Pediatr Diabetes 18:895-902
East, Patricia; Lozoff, Betsy; Blanco, Estela et al. (2017) Infant iron deficiency, child affect, and maternal unresponsiveness: Testing the long-term effects of functional isolation. Dev Psychol 53:2233-2244

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