Heart valve replacement therapy is in the midst of a major paradigm shift. Improvements in imaging, catheter technology and stent design have made transcatheter replacement of the aortic and pulmonic valves clinical realities. A transcatheter approach to mitral valve replacement (TMVR) would represent a major advance in treatment since approximately 2.4 million Americans suffer from moderate to severe ischemic mitral regurgitation (IMR) with the vast majority being deemed too sick or debilitated to tolerate open-heart surgery. Successful TMVR requires: 1) a sutureless anchoring mechanism~ 2) a perivalvular sealing strategy and 3) foldability. As the result of extensive preliminary work we have developed a novel anchoring and sealing mechanism for TMVR. The current prototype is a self-expanding valved stent constructed from a polytetrafluoroethylene covered nitinol wire frame. Anchoring is facilitated by arms emanating from the ventricular end of the device which are designed to atraumatically insinuate themselves around chordae and leaflets. Our sealing mechanism relies on the flexibility of the stent design which allows the device to be slightly oversized thereby permitting the device to conform snuggly to the annulus and leaflet cone. In preliminary work we have demonstrated that our TMVR concept can anchor and seal robustly in large animal models. The goal of the proposed project is to optimize the design of the current prototype to maximize device foldability and delivery without compromising valve fixation and seal. The development process will follow a graded approach.
Specific Aim 1 is to further develop the anchoring and sealing technology using open surgical techniques to evaluate design iterations. The result of this development stage will be a sutureless mitral valve replacement.
Specific Aim 2 A will be to develop a minimally invasive surgical delivery system which will ultimately facilitate off pump mitral valve replacement via a small right thoracotomy in humans.
Specific Aim 2 B is to further enhance the delivery system to allow mitral valve replacement via peripheral vein and transatrial septal approach.
Heart valve replacement is in the midst of a major paradigm shift. New technology has made transcatheter aortic valve replacement a reality. The vast majority of the 2.4 million Americans suffering from ischemic mitral regurgitation are too sick to tolerate valve surgery. As a result transcatheter mitral valve replacement (TMVR) would be a major advance. This project uses an innovative design strategy for developing a TMVR system.
| Gillespie, Matthew J; Aoki, Chikashi; Takebayashi, Satoshi et al. (2015) Development of off-pump mitral valve replacement in a porcine model. Ann Thorac Surg 99:1408-12 |
| Gorman, Robert C; Gillespie, Matthew J; Gorman 3rd, Joseph H (2014) Surgery for severe ischemic mitral regurgitation. N Engl J Med 370:1462 |
| Witschey, Walter R T; Contijoch, Francisco; McGarvey, Jeremy R et al. (2014) Real-time magnetic resonance imaging technique for determining left ventricle pressure-volume loops. Ann Thorac Surg 97:1597-603 |
| Jassar, Arminder S; Vergnat, Mathieu; Jackson, Benjamin M et al. (2014) Regional annular geometry in patients with mitral regurgitation: implications for annuloplasty ring selection. Ann Thorac Surg 97:64-70 |
| Clark, James E; Marber, Michael S (2013) Advancements in pressure-volume catheter technology - stress remodelling after infarction. Exp Physiol 98:614-21 |
