The Jackson Heart Study (JHS) was designed to collect clinical, laboratory, imaging, genetic, and environmental data that could provide insights into the determinants and development of cardiovascular and related diseases in African Americans (AA) residing in the Jackson, MS community. Between 2000 and 2012, 5301 AA men and women participated at a baseline and two additional clinic examinations. Obesity and diabetes are important contributors to cardiovascular outcomes and the overall health disparities observed between AAs and whites in the United States. Both conditions are highly prevalent among those enrolled in JHS. The overall goal of this proposal is to enhance the scientific output of the JHS with respect to obesity/diabetes and its cardiometabolic and vascular outcomes. We propose to conduct in-depth cross- sectional and longitudinal analyses of obesity and glucometabolic parameters, and select outcomes (incident diabetes, subclinical and clinical cardiovascular disease) by engaging scientists in the newly established JHS Obesity Diabetes Working Group (ODWG). The ODWG will function as a virtual team, utilizing a combination of teleconferences, in person meetings, and internet-based file sharing tools, and will include Wake Forest, JHS and other interested investigators and trainees. The investigative team includes expertise in epidemiology, biostatistics, imaging, diabetes, obesity, and cardiovascular disease. We also have an extant relationship with JHS as Wake Forest served as the reading center for the CT and MRI studies performed at exams 2 and 3. A focus of ODWG activities includes mentoring junior investigators and trainees. We also expect that analysis and dissemination of these data will spur the application for separate funding for ancillary studies.

Public Health Relevance

This research seeks to better understand obesity and diabetes in African American adults by establishing a working group to analyze obesity and diabetes-related data collected by the Jackson Heart Study in 5301 African American men and women. Through monthly conference calls and yearly in-person meetings with Jackson Heart scientists we will write papers using these data, and mentor junior faculty and trainees.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL117285-01
Application #
8441279
Study Section
Special Emphasis Panel (ZHL1-CSR-B (O2))
Program Officer
Harman, Jane
Project Start
2013-07-15
Project End
2017-06-30
Budget Start
2013-07-15
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$227,076
Indirect Cost
$73,646
Name
Wake Forest University Health Sciences
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Glover, LáShauntá M; Bertoni, Alain G; Golden, Sherita H et al. (2018) Sex differences in the association of psychosocial resources with prevalent type 2 diabetes among African Americans: The Jackson Heart Study. J Diabetes Complications :
Basu, Sanjay; Sussman, Jeremy B; Berkowitz, Seth A et al. (2018) Validation of Risk Equations for Complications of Type 2 Diabetes (RECODe) Using Individual Participant Data From Diverse Longitudinal Cohorts in the U.S. Diabetes Care 41:586-595
Bell, Ronny A; Chen, Haiying; Saldana, Santiago et al. (2018) Comparison of Measures of Adiposity and Cardiovascular Disease Risk Factors Among African American Adults: the Jackson Heart Study. J Racial Ethn Health Disparities 5:1230-1237
Joseph, Joshua J; Echouffo-Tcheugui, Justin B; Talegawkar, Sameera A et al. (2017) Modifiable Lifestyle Risk Factors and Incident Diabetes in African Americans. Am J Prev Med 53:e165-e174
Auerbach, Brandon J; Katz, Ronit; Tucker, Katherine et al. (2017) Factors associated with maintenance of body mass index in the Jackson Heart Study: A prospective cohort study secondary analysis. Prev Med 100:95-100
Joseph, Joshua J; Echouffo-Tcheugui, Justin B; Kalyani, Rita R et al. (2017) Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans: The Jackson Heart Study. JACC Heart Fail 5:642-651
Effoe, Valery S; Wagenknecht, Lynne E; Echouffo Tcheugui, Justin B et al. (2017) Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study. J Am Heart Assoc 6:
Kalyani, Rita Rastogi; Ji, Nan; Carnethon, Mercedes et al. (2017) Diabetes, depressive symptoms, and functional disability in African Americans: the Jackson Heart Study. J Diabetes Complications 31:1259-1265
Effoe, Valery S; Carnethon, Mercedes R; Echouffo-Tcheugui, Justin B et al. (2017) The American Heart Association Ideal Cardiovascular Health and Incident Type 2 Diabetes Mellitus Among Blacks: The Jackson Heart Study. J Am Heart Assoc 6:
Casanova, Ramon; Saldana, Santiago; Simpson, Sean L et al. (2016) Prediction of Incident Diabetes in the Jackson Heart Study Using High-Dimensional Machine Learning. PLoS One 11:e0163942

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