Evaluation and optimal management of patients with known or suspected ischemic cardiomyopathy requires an assessment of the magnitude and extent of myocardial ischemia as well as the extent of myocardial infarction and scar. While PET myocardial perfusion imaging offers the most robust method to evaluate the presence and severity of ischemia, it is currently limited by the degradation due to both cardiac and respiratory motion. On the other hand, cardiac MR (CMR) currently offers the most accurate method to detect the presence and assess the extent of myocardial scar. It can also identify clinically important late gadolinium enhancement patterns associated with various non-ischemic cardiomyopathies and provides an assessment of global and regional wall motion abnormalities. Furthermore, CMR can be used to estimate the transmural extent of a given infarct, which directly correlates with the likelihood of recovery post coronary revascularization, and thus accurately identifies viable myocardium. However, quantification of the severity of ischemia, particularly when concomitant scar is also present, is less established with CMR. In order to take advantage of the inherent strengths of each technique and resolve fundamental limitations of these modalities, we propose to use simultaneous PET-MR to provide a comprehensive assessment of viable myocardium as well as an assessment of residual ischemia in patients with non-transmural infarctions. We will develop a novel list-mode PET reconstruction framework that incorporates cardiac and respiratory motion measured by MR into PET emission system matrix as well as the time-dependent attenuation map and the position dependent point spread function.

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In order to take advantage of the inherent strengths of PET myocardial perfusion and cardiac MR, we propose to use simultaneous PET-MR data acquisition for a comprehensive assessment of both scar (the absence of which identifies viable myocardium) as well as ischemia (the presence of which identifies expected benefit from coronary revascularization). To demonstrate the superiority of the novel PET-MR cardiac exam, we will test how this technique can address one of the most challenging aspects of non-invasive myocardial perfusion imaging: the identification and quantification of residual per-infarct ischemia in patients with prior myocardial infarction.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
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Biomedical Imaging Technology Study Section (BMIT)
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Danthi, Narasimhan
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Massachusetts General Hospital
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Guo, Rong; Petibon, Yoann; Ma, Yixin et al. (2018) MR-based motion correction for cardiac PET parametric imaging: a simulation study. EJNMMI Phys 5:3
Lai, X; Petibon, Y; El Fakhri, G et al. (2018) Joint reconstruction of rest/stress myocardial perfusion SPECT. Phys Med Biol 63:135019
Petibon, Yoann; Guehl, Nicolas J; Reese, Timothy G et al. (2017) Impact of motion and partial volume effects correction on PET myocardial perfusion imaging using simultaneous PET-MR. Phys Med Biol 62:326-343
Petibon, Yoann; Rakvongthai, Yothin; El Fakhri, Georges et al. (2017) Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies. Phys Med Biol 62:3539-3565
Lorsakul, Auranuch; Fakhri, Georges El; Worstell, William et al. (2016) Numerical observer for atherosclerotic plaque classification in spectral computed tomography. J Med Imaging (Bellingham) 3:035501
Zhu, W; Ouyang, J; Rakvongthai, Y et al. (2016) A Bayesian spatial temporal mixtures approach to kinetic parametric images in dynamic positron emission tomography. Med Phys 43:1222-34
Huang, Chuan; Petibon, Yoann; Ouyang, Jinsong et al. (2015) Accelerated acquisition of tagged MRI for cardiac motion correction in simultaneous PET-MR: phantom and patient studies. Med Phys 42:1087-97
Huang, C; Ouyang, J; Reese, T G et al. (2015) Continuous MR bone density measurement using water- and fat-suppressed projection imaging (WASPI) for PET attenuation correction in PET-MR. Phys Med Biol 60:N369-81
Lorsakul, Auranuch; Li, Quanzheng; Trott, Cathryn M et al. (2014) 4D numerical observer for lesion detection in respiratory-gated PET. Med Phys 41:102504
Ouyang, Jinsong; Petibon, Yoann; Huang, Chuan et al. (2014) Quantitative Simultaneous PET-MR Imaging. J Med Imaging (Bellingham) 9083:908325

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