Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with poor survival, limited treatment options and no known cure. Early detection and treatment is a promising approach that could potentially improve clinical outcomes of patients affected with this devastating disease. Cigarette smoking is the most important environmental risk factor for the development of ILD; we have recently shown that smokers without a prior diagnosis of ILD have radiographic interstitial lung abnormalities (ILA) that are associated with physiologic, functional and molecular changes. Although these findings suggest that a subset of smokers with subclinical ILD will progress to develop clinically significant pulmonary fibrosis, large prospective longitudinal studies are required to define clinical and molecular features associated with subclinical ILD in smokers. In this proposal we will prospectively study a large cohort of smokers enrolled in the Pittsburgh Lung Screening Study (PLuSS).
We aim to define clinical and molecular determinants that predict development and longitudinal progression of ILA detected by computed tomography over a 10-year mean follow-up period. We hypothesize that select clinical and molecular features that portend a poor prognosis in IPF patients predict development and progression of subclinical ILD in smokers. To test this hypothesis we will address the following specific aims:
Specific Aim 1 : Determine prevalence and long-term longitudinal progression of subclinical ILD in smokers enrolled in PLuSS.
Specific Aim 2 : Define clinical and molecular determinants that predict progression of subclinical ILD in smokers.
Specific Aim 3 : Identify clinical and molecular determinants that predict the development of subclinical ILD in smokers. The successful completion of this research will provide us with a better understanding of the characteristics and natural history of subclinical ILD and novel non- invasive ways to identify smokers at risk for progression of subclinical ILD.

Public Health Relevance

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease, patients affected with the disease have a limited life span and treatment options, and presently there is no cure for this disease. Several findings suggest that early detection followed by treatment is a promising approach that could potentially improve the live of patients affected with this devastating disease. Cigarette smoking is the most important risk factor for the development of pulmonary fibrosis; millions of people in the United States have a history of smoking and therefore are at risk of developing lung disease. In this proposal we will study a large cohort of smokers over time and determine the clinical characteristics and blood markers associated with early stage of pulmonary fibrosis. This study will provide us with a better understanding of how people develop lung fibrosis and novel non-invasive ways to identify people at risk of developing this important disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL129920-03
Application #
9319794
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Vuga, Louis Justine
Project Start
2015-09-17
Project End
2018-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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