Heart failure (HF) is major and growing public health problem especially in older women. Despite advances in the treatment of established HF, prognosis remains poor in the elderly, therefore preventive efforts are needed. Lack of physical activity (PA) is a potent prospective risk factor for HF; while increased levels of PA are associated with reduced risk of HF in observational studies, the evidence that maintaining high levels of physical activity or increasing PA in sedentary individuals reduces the risk of heart failure is not presently available. A novel PA pragmatic trial embedded within the Women's Health Initiative (WHI) entitled WHI Strong and Healthy trial (WHISH) has been recently funded and will evaluate whether increasing physical activity, reducing sedentary behavior and increasing muscle strength through resistance training will reduce the risk of atherosclerotic cardiovascular disease but not the important outcome of HF. WHISH-2-Prevent Heart Failure will evaluate the effect of this RCT on incident HF and HF burden (all heart failure hospitalizations and CVD death in those with antecedent HF) as well as perform dose-finding analyses. WHISH-2-Prevent Heart Failure will be the first, largest, and longest primary prevention exercise trial ever performed in the highest risk group for HF-elderly women. An imbedded accelerometer study will allow for a dose-finding analysis regardless of the RCT results using newly developed MET-equivalent indices for elderly women.

Public Health Relevance

This WHISH-2-Prevent Heart Failure study will evaluate whether randomization to a physical activity and strength training intervention will reduce the risk of Heart Failure and its burden in 49,936 elderly women who have the greatest risk of developing heart failure. In addition, it will perform a dose finding analysis to determine the type, frequency and intensity of physical activity that lead to reduced risk of heart failure in elderly women.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL130591-03
Application #
9513036
Study Section
Cancer, Heart, and Sleep Epidemiology B Study Section (CHSB)
Program Officer
Cooper, Lawton S
Project Start
2016-08-01
Project End
2021-03-31
Budget Start
2018-06-01
Budget End
2019-03-31
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Memorial Hospital of Rhode Island
Department
Type
DUNS #
069852580
City
Pawtucket
State
RI
Country
United States
Zip Code