Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL130864-03S1
Application #
9674170
Study Section
Program Officer
Chang, Henry
Project Start
2016-03-15
Project End
2020-02-29
Budget Start
2018-08-27
Budget End
2019-02-28
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Nebraska Lincoln
Department
Biochemistry
Type
Earth Sciences/Resources
DUNS #
555456995
City
Lincoln
State
NE
Country
United States
Zip Code
68503
Miller, Colton M; Xu, Yongmei; Kudrna, Katrina M et al. (2018) 3-O sulfation of heparin leads to hepatotropism and longer circulatory half-life. Thromb Res 167:80-87
Miller, Colton M; Wan, W Brad; Seth, Punit P et al. (2018) Endosomal Escape of Antisense Oligonucleotides Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation. Nucleic Acid Ther 28:86-96
Bano, Fouzia; Tammi, Markku I; Kang, David W et al. (2018) Single-Molecule Unbinding Forces between the Polysaccharide Hyaluronan and Its Binding Proteins. Biophys J 114:2910-2922
Miller, Colton M; Tanowitz, Michael; Donner, Aaron J et al. (2018) Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver. Nucleic Acid Ther 28:119-127
Pirie, Elaine; Ray, Shayoni; Pan, Calvin et al. (2018) Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet 14:e1007732
Gaus, Hans; Miller, Colton M; Seth, Punit P et al. (2018) Structural Determinants for the Interactions of Chemically Modified Nucleic Acids with the Stabilin-2 Clearance Receptor. Biochemistry 57:2061-2064
Cabral, Fatima; Miller, Colton M; Kudrna, Katrina M et al. (2018) Purification of Hepatocytes and Sinusoidal Endothelial Cells from Mouse Liver Perfusion. J Vis Exp :
Baggenstoss, Bruce A; Harris, Edward N; Washburn, Jennifer L et al. (2017) Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X7-B motif. Glycobiology 27:154-164
Xu, Yongmei; Chandarajoti, Kasemsiri; Zhang, Xing et al. (2017) Synthetic oligosaccharides can replace animal-sourced low-molecular weight heparins. Sci Transl Med 9:
Natarajan, Vaishaali; Harris, Edward N; Kidambi, Srivatsan (2017) SECs (Sinusoidal Endothelial Cells), Liver Microenvironment, and Fibrosis. Biomed Res Int 2017:4097205

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