Systemic Inflammatory Response and organ failure (SIRS-CPB) is a major problem following cardiac surgery. The incidence increases with the amount of time on cardiopulmonary bypass. The mechanism is unknown. Our preliminary studies indicate that white cell activation by surface exposure during CPB is the cause. Our studies indicate that the white cell activation can be prevented by nitric oxide (NO) in the gas to the heart/lung machine. This research is designed to determine the cause of SIRS-CPB and prevention with NO.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL141509-03
Application #
10113414
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Program Officer
Fenton, Kathleen Nelle
Project Start
2019-02-01
Project End
2023-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
3
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Surgery
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109