The first goal of this project is to develop Bayesian statistical methods for using historical information in analyzing data from clinical trials. This has most relevance in those settings in which additional randomized data are difficult to obtain for ethical or other reasons. In the context of two actual medical settings the plan is to: (1) develop the model suggested in the proposal,(2) elicit necessary probability distributions,(3) write computer software to carry out the necessary calculations,(4) compare with existing metaanalysis procedures. The second goal is to carry out a decision making process in the context of a prophylactic trial. This will entail eliciting probability distributions and loss functions from the investigators and others. These will be used to evaluate the various possible actions, such as in deciding whether or not to stop a clinical trial.

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Research Project (R01)
Project #
7R01HS006475-02
Application #
3372129
Study Section
Special Emphasis Panel (HCT)
Project Start
1991-09-30
Project End
1993-09-29
Budget Start
1991-09-30
Budget End
1993-09-29
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Organized Research Units
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705