Differentials in mortality by socio-economic status have been documented in the USA and UK. Less is known about health related functioning in the physiological, psychological and social role. These aspects are important in studies of medical outcomes, and it is necessary to examine factors other than medical care which are related to functioning. This study will test the use of a potentially valuable tool, the General Health Survey used in the Medical Outcome study (MOS-GHS), in a cross national study. A prospective study (Whitehall II) has been set up to examine causes of socioeconomic inequalities in health among civil servants in London. The present proposal seeks to supplement this study with measures of health related functioning. The objectives are: a) to validate the MOS-General Health Survey in a general population sample in Britain b) to examine the relationship between functional status and other self-reported and measured components of health c) to examine the relationships between socio-economic status, functional status, and perceived well-being d) to assess the impact on functional status and perceived well being of features of lifestyle, work environment, social networks and types of social support, and socioeconomic circumstances, both current and during childhood, e) to establish a cohort in which the prospective significance of functional status can be investigated. Subsequent sickness absence, major morbidity and mortality will be related to the baseline measures of functional status. These objectives will be met through the enhancement of the Whitehall II study. In this study a cohort of 10,314 male and female civil servants aged 35-55 completed an extensive questionnaire and a screening examination between 1985 and 1988. In 1989 a repeat questionnaire survey was carried out. The cohort is being followed through sickness absence records, major morbidity reporting and mortality registrations. The cohort will be rescreened in 1991-1992. This proposal seeks to include the MOS-GHS and other measures of functioning in the study at the time of this rescreen. Selfcompletion questionnaires will be given to the entire cohort, with a random subsample of 200 participants undergoing a validation interview. Data from this survey will be linked to the data from the baseline study, the repeat questionnaire survey, sickness absence reports, major morbidity recording and mortality and cancer registrations.

National Institute of Health (NIH)
Agency for Healthcare Research and Quality (AHRQ)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (HSDG)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of London
United Kingdom
Zip Code
Abell, Jessica G; Shipley, Martin J; Ferrie, Jane E et al. (2016) Association of chronic insomnia symptoms and recurrent extreme sleep duration over 10 years with well-being in older adults: a cohort study. BMJ Open 6:e009501
White, Jon; Sofat, Reecha; Hemani, Gibran et al. (2016) Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol 4:327-36
Morris, Richard W; Taylor, Amy E; Fluharty, Meg E et al. (2015) Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open 5:e008808
Masset, Gabriel; Scarborough, Peter; Rayner, Mike et al. (2015) Can nutrient profiling help to identify foods which diet variety should be encouraged? Results from the Whitehall II cohort. Br J Nutr 113:1800-9
Akbaraly, Tasnime N; Shipley, Martin J; Ferrie, Jane E et al. (2015) Long-term adherence to healthy dietary guidelines and chronic inflammation in the prospective Whitehall II study. Am J Med 128:152-160.e4
Skipworth, James R A; Nijmeijer, Rian M; van Santvoort, Hjalmar C et al. (2015) The effect of renin angiotensin system genetic variants in acute pancreatitis. Ann Surg 261:180-8
Talmud, Philippa J; Cooper, Jackie A; Morris, Richard W et al. (2015) Sixty-five common genetic variants and prediction of type 2 diabetes. Diabetes 64:1830-40
Stansfeld, S A; Shipley, M (2015) Noise sensitivity and future risk of illness and mortality. Sci Total Environ 520:114-9
Futema, M; Kumari, M; Boustred, C et al. (2015) Would raising the total cholesterol diagnostic cut-off from 7.5 mmol/L to 9.3 mmol/L improve detection rate of patients with monogenic familial hypercholesterolaemia? Atherosclerosis 239:295-8
Linneberg, Allan; Jacobsen, Rikke K; Skaaby, Tea et al. (2015) Effect of Smoking on Blood Pressure and Resting Heart Rate: A Mendelian Randomization Meta-Analysis in the CARTA Consortium. Circ Cardiovasc Genet 8:832-41

Showing the most recent 10 out of 323 publications