This project develops methods to assess patient preferences toward alternative states of health for use in cost-effectiveness analysis of pharmaceutical therapies. Its uses multimedia-based computer interviews in order to measure aspects of health, to refine risk-risk and risk- dollar tradeoff techniques for preference assessment, and its implements several tests of reliability and of validity. The preference assessment technology is then applied to cost-effectiveness analysis of alglucerase, a new treatment of Gaucher disease. For this drug, like many others effects on quality of life are likely to be more important than survival effects. The results of the analysis should help to quantify interindividual variation in preferences, and intertemporal consistency in preferences. If successful, the project will produce an easily-implemented and reliable instrument for the assessment of preferences and quality of life for use in cost-effectiveness analyses.
| Lenert, L A; Cher, D J; Goldstein, M K et al. (1998) The effect of search procedures on utility elicitations. Med Decis Making 18:76-83 |
| Clarke, A E; Goldstein, M K; Michelson, D et al. (1997) The effect of assessment method and respondent population on utilities elicited for Gaucher disease. Qual Life Res 6:169-84 |
| Hornberger, J; Lenert, L A (1996) Variation among quality-of-life surveys. Theory and practice. Med Care 34:DS23-33 |
| Beutler, E; Garber, A M (1994) Alglucerase for Gaucher's disease: dose, costs and benefits. Pharmacoeconomics 5:453-9 |
| Goldstein, M K; Clarke, A E; Michelson, D et al. (1994) Developing and testing a multimedia presentation of a health-state description. Med Decis Making 14:336-44 |
