This project is intended to demonstrate the feasibility and viability of integrating specialized tools to access and manage high performance molecular biology applications in a heterogeneous environment. By this integration, solutions to increasingly more difficult problems in the biomedical sciences can be realized. At the same time, this project will demonstrate the ability to perform this integration in a relatively transparent fashion to the user. With the evolution of increasingly more powerful computer architectures, computer networks and application development tools supporting distributed computing environments, this project will utilize some of these evolving technologies and direct them toward solving problems in the biomedical sciences. In particular, the massively parallel Connection Machines (CM-2 and CM-5) and the vector capabilities of the CRAY Y/MP-832 will be combined to solve computationally intensive evolutionary relatedness of specific genes and protein problems as well as other multiple sequence alignment problems in molecular biology and molecular chemistry. In addition, the output from these systems will be utilized to access sequence specific information found in the cited literature obtainable from various literature databases (e.g., Medline and others). By integrating the tools and utilizing the resources that best address various aspects of these scientific research problems, a researcher can gain access to and utilize the most sophisticated services available from a common access point, the researcher's local workstation. By utilizing open system concepts and distributed computing tools, practitioners can utilize these integrated tools from a variety of heterogeneous devices in a totally distributed, national computing environment.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Research Project (R01)
Project #
1R01LM005513-01
Application #
3374432
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Project Start
1992-09-30
Project End
1995-09-29
Budget Start
1992-09-30
Budget End
1993-09-29
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Missouri-Columbia
Department
Type
Schools of Arts and Sciences
DUNS #
112205955
City
Columbia
State
MO
Country
United States
Zip Code
65211
Calcutt, M J; Schmidt, F J (1994) Gene organization in the bleomycin-resistance region of the producer organism Streptomyces verticillus. Gene 151:17-21
Patrick, T B; Springer, G K (1994) Classifying and identifying servers for biomedical information retrieval. Proc Annu Symp Comput Appl Med Care :93-7
Springer, G K; Patrick, T B (1993) A service-oriented information sources database for the biological sciences. Proc Int Conf Intell Syst Mol Biol 1:380-6