The goal of this project to develop and evaluate a learning electronic medical records (L-EMR) system that draws a physician's attention to the right data, at the right time. It learns how to do so by analyzing patterns of patient data access f many physicians in many past cases in the EMR, and learning which EMR data to highlight that are relevant for making clinical decisions in a given patient. The hypothesis underlying this research is that the L-EMR system will have sufficiently high precision and recall in highlighting relevant data, decrease the average time to assess an intensive care unit (ICU) patient case, and be judged by critical care medicine (CCM) physicians to be clinically useful.
The first aim of this project is develop a highly-usable L-EMR user interface. The L-EMR user interface will include zoomable time-series displays of lab-results, med-orders, and vital signs. Usability studies of the L-EMR user interface will guide revisions and enhancements.
The second aim of the project is to train statistical models that can be applied to a patient case to predict relevant lab-results, med-orders, and vital signs. We will enlist CCM physicians to review a set of retrospective ICU patient cases on a focused set of clinical conditions. Participants will review these cases as if they were active patients, identifying relevant lab- results, med-orders, and vital signs. We will train and evaluate statistical models to predict relevant data, and identify the best performing algorithm to include in the L-EMR system.
The third aim of the project is to evaluate the L-EMR system. We will recruit CCM physicians to evaluate an L-EMR system based on user interfaces from Aim 1 and statistical models trained using the best performing algorithm in Aim 2 to highlight relevant data items. We will measure the precision and recall of the data-highlighting functionality for assessing patient cases and making clinical decisions (e.g., lab and medication orders), the time required to assess cases with and without the highlighting, and physicians' assessments of the strengths and weaknesses of the L-EMR system. If the results of these experiments are positive, as anticipated, this project will introduce a computational method that has significant potential to improve future EMR systems and enhance patient care.

Public Health Relevance

The purpose of this research is to develop and evaluate a learning electronic medical records (EMR) system that draws a physician's attention to the right data, at the right time. The system works by analyzing patterns of EMR usage of physicians, and learning which EMR data to highlight that are relevant in a given patient. The main idea underlying the approach is that patterns of past EMR usage patterns can be exploited to selectively highlight clinically useful patient data.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Research Project (R01)
Project #
5R01LM012095-02
Application #
9144440
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Program Officer
Sim, Hua-Chuan
Project Start
2015-09-15
Project End
2019-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
2
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Naeini, Mahdi Pakdaman; Cooper, Gregory F (2018) Binary Classifier Calibration Using an Ensemble of Piecewise Linear Regression Models. Knowl Inf Syst 54:151-170
Tajgardoon, Mohammadamin; Wagner, Michael M; Visweswara, Shyam et al. (2018) A Novel Representation of Vaccine Efficacy Trial Datasets for Use in Computer Simulation of Vaccination Policy. AMIA Jt Summits Transl Sci Proc 2017:389-398
Castro, Sergio M; Tseytlin, Eugene; Medvedeva, Olga et al. (2017) Automated annotation and classification of BI-RADS assessment from radiology reports. J Biomed Inform 69:177-187
King, Andrew J; Hochheiser, Harry; Visweswaran, Shyam et al. (2017) Eye-tracking for clinical decision support: A method to capture automatically what physicians are viewing in the EMR. AMIA Jt Summits Transl Sci Proc 2017:512-521
Culbertson, Adam; Goel, Satyender; Madden, Margaret B et al. (2017) The Building Blocks of Interoperability. A Multisite Analysis of Patient Demographic Attributes Available for Matching. Appl Clin Inform 8:322-336
Bhavnani, Suresh K; Chen, Tianlong; Ayyaswamy, Archana et al. (2017) Enabling Comprehension of Patient Subgroups and Characteristics in Large Bipartite Networks: Implications for Precision Medicine. AMIA Jt Summits Transl Sci Proc 2017:21-29
Lustgarten, Jonathan Lyle; Balasubramanian, Jeya Balaji; Visweswaran, Shyam et al. (2017) Learning Parsimonious Classification Rules from Gene Expression Data Using Bayesian Networks with Local Structure. Data (Basel) 2:
Tenenbaum, Jessica D; Bhuvaneshwar, Krithika; Gagliardi, Jane P et al. (2017) Translational bioinformatics in mental health: open access data sources and computational biomarker discovery. Brief Bioinform :
Hauskrecht, Milos; Batal, Iyad; Hong, Charmgil et al. (2016) Outlier-based detection of unusual patient-management actions: An ICU study. J Biomed Inform 64:211-221
Pineda, Arturo López; Ogoe, Henry Ato; Balasubramanian, Jeya Balaji et al. (2016) On Predicting lung cancer subtypes using 'omic' data from tumor and tumor-adjacent histologically-normal tissue. BMC Cancer 16:184

Showing the most recent 10 out of 15 publications