A series of seven studies on sleep is proposed: 1. A study of behavioral and functional characteristics of a rat state characterized by low EEG, low EMG, and high theta amplitudes aims to clarify where this state belongs relative to wakefulness and sleep stages. 2. To increase our understanding of underlying oscillators, we propose to compare relationships among circadian rhythms of sleep, temperature, and activity in the rat under several light:dark schedules. 3. To understand why diurnal sleep rhythms changes with age, we propose to compare the rhythms of young and old rats under """"""""normal"""""""" and phase reversed lighting schedules and during """"""""free-runs"""""""". 4. To develop measures of sleep intensity, we propose to compare frequency and amplitude characteristics of the sleep EEG following sleep deprivation with baseline recordings. 5. We propose to develop improved techniques for sleep depriving animals through the use of an automated system that delivers stimuli contingent upon an animal's state. 6. To understand the large individual differences in EEG slow wave activity during sleep, we propose to examine how they are correlated with a number of physiological, psychological, and sleep parameters. 7. We propose to describe the visual characteristics of dreams by having subjects choose photographs which match the visual characteristics of their own dreams. We also propose to determine how these visual characteristics are related to phasic events during sleep.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH004151-26
Application #
3374546
Study Section
(SRC)
Project Start
1975-09-01
Project End
1988-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
26
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
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Benca, R M; Obermeyer, W H; Bergmann, B M et al. (1993) Failure to induce rapid eye movement sleep by dark pulses in pigmented inbred rat strains. Physiol Behav 54:1211-4
Bergmann, B M; Landis, C A; Zenko, C E et al. (1993) Sleep deprivation in the rat: XVII. Effect of aspirin on elevated body temperature. Sleep 16:221-5
Landis, C A; Collins, B J; Cribbs, L L et al. (1993) Expression of Egr-1 in the brain of sleep deprived rats. Brain Res Mol Brain Res 17:300-6
Landis, C A; Bergmann, B M; Ismail, M M et al. (1992) Sleep deprivation in the rat: XV. Ambient temperature choice in paradoxical sleep-deprived rats. Sleep 15:13-20
Tsai, L L; Bergmann, B M; Rechtschaffen, A (1992) Sleep deprivation in the rat: XVI. Effects in a light-dark cycle. Sleep 15:537-44
Leung, C; Bergmann, B M; Rechtschaffen, A et al. (1992) Heritability of dark pulse triggering of paradoxical sleep in rats. Physiol Behav 52:127-31
Prete, F R; Bergmann, B M; Holtzman, P et al. (1991) Sleep deprivation in the rat: XII. Effect on ambient temperature choice. Sleep 14:109-15
Pilcher, J J; Bergmann, B M; Refetoff, S et al. (1991) Sleep deprivation in the rat: XIII. The effect of hypothyroidism on sleep deprivation symptoms. Sleep 14:201-10
Benca, R M; Bergmann, B M; Leung, C et al. (1991) Rat strain differences in response to dark pulse triggering of paradoxical sleep. Physiol Behav 49:83-7

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