Abstract

The long term objective is to achieve a better understanding of the association cortex and its relation to the primary sensory cortex. The neocortex is the highest level of the brain and the study therefore has implication for mental health. The starting point for the proposed research is the discovery that association cortex as well as the sensory cortex is the target of sensory pathways that are relayed by the dorsal thalamus. The questions raised in the specific aims concern differences in the primary and secondary pathways. Each pathway is influenced, but not in the same way by centers in the brain stem that are not modality-specific -- the reticular formation and the reticular nucleus.
The aim i s to identify the functional significance of the modulating influences and their differences. The targets of the secondary pathways in the cortex and the cortical layers of terminations must be identified to understand the relation between sensory and association cortex inasmuch as the areas called """"""""association cortex"""""""" receive thalamic projections from the secondary pathways. Cortico-cortical connections and descending projections from cortex can be viewed as the basis for integration between primary and secondary pathways.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH004849-30
Application #
3374550
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1985-12-01
Project End
1994-02-28
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
30
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Conley, M; Friederich-Ecsy, B (1993) Functional organization of the ventral lateral geniculate complex of the tree shrew (Tupaia belangeri): II. Connections with the cortex, thalamus, and brainstem. J Comp Neurol 328:21-42
Conley, M; Friederich-Ecsy, B (1993) Functional organization of the ventral lateral geniculate complex of the tree shrew (Tupaia belangeri): I. Nuclear subdivisions and retinal projections. J Comp Neurol 328:1-20
Diamond, I T; Fitzpatrick, D; Schmechel, D (1993) Calcium binding proteins distinguish large and small cells of the ventral posterior and lateral geniculate nuclei of the prosimian galago and the tree shrew (Tupaia belangeri). Proc Natl Acad Sci U S A 90:1425-9
Diamond, I T; Fitzpatrick, D; Conley, M (1992) A projection from the parabigeminal nucleus to the pulvinar nucleus in Galago. J Comp Neurol 316:375-82
Conley, M; Wilson, K F (1992) Dendritic organization of class II (inter)neurons in the dorsal lateral geniculate nucleus of the tree shrew: observations based on Golgi, immunocytochemical, and biocytin methods. J Comp Neurol 319:51-65
Diamond, I T; Conley, M; Fitzpatrick, D et al. (1991) Evidence for separate pathways within the tecto-geniculate projection in the tree shrew. Proc Natl Acad Sci U S A 88:1315-9
Fitzpatrick, D; Raczkowski, D (1990) Innervation patterns of single physiologically identified geniculocortical axons in the striate cortex of the tree shrew. Proc Natl Acad Sci U S A 87:449-53
Conley, M; Raczkowski, D (1990) Sublaminar organization within layer VI of the striate cortex in Galago. J Comp Neurol 302:425-36
Raczkowski, D; Fitzpatrick, D (1990) Terminal arbors of individual, physiologically identified geniculocortical axons in the tree shrew's striate cortex. J Comp Neurol 302:500-14
Raczkowski, D; Fitzpatrick, D (1989) Organization of cholinergic synapses in the cat's dorsal lateral geniculate and perigeniculate nuclei. J Comp Neurol 288:676-90

Showing the most recent 10 out of 18 publications