Abstract

We propose to investigate the interrelationships of various hormones neuropeptides and neurotransmitters to metabolic state and the normal development of brain and other vital organs and to study the mechanisms by which these neurochemicals mediate the perturbations in growth, development and metabolism resulting from """"""""maternal deprivation"""""""".
Our aim i s to elucidate the role that the CNS plays in the control of early development through the regulation of neurochemical release and cell metabolism and identify the brain regions involved in mediating the effects of these neurochemicals and environmental influences on vital organ growth and function in normal and abnormal states. The basic experimental approach utilizes assessment of multiple physiological and biochemical parameters in developing organs primarily brain, lung, heart and liver as indices of altered functional maturation of these tissues directly resulting from specific sensory or nutritional conditions innate to the maternal deprivation paradigm. Principal systems analyzed in these studies include metabolic (polyamine and glucose) endocrine (GH insulin, and glucocorticoid, i.e., CRF, ACTH, corticosterone) and neurotransmitter (serotonin, catecholamine, endorphin and opiate).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH013688-22
Application #
3374624
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1976-09-01
Project End
1993-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
22
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Bartolome, J V; Wang, S; Schanberg, S M et al. (1999) Involvement of c-myc and max in CNS beta-endorphin modulation of hepatic ornithine decarboxylase responsiveness to insulin in rat pups. Life Sci 64:PL87-91
Bartolome, J V; Johnston, J G; Schanberg, S M (1994) The inhibition of liver ornithine decarboxylase expression in neonatal rats by maternal separation or CNS beta-endorphin is independent of the pituitary. Life Sci 54:679-86
Borowsky, B; Kuhn, C M (1991) Monoamine mediation of cocaine-induced hypothalamo-pituitary-adrenal activation. J Pharmacol Exp Ther 256:204-10
Bartolome, J V; Bartolome, M B; Lorber, B A et al. (1991) Effects of central administration of beta-endorphin on brain and liver DNA synthesis in preweanling rats. Neuroscience 40:289-94
Johnson, M D; McMillian, M K; Schanberg, S M (1991) Alterations in cardiovascular responsiveness and adrenoceptor binding during catecholamine infusion hypertension in rats. Proc Soc Exp Biol Med 197:67-73
Greer, N L; Bartolome, J V; Schanberg, S M (1991) Further evidence for the hypothesis that beta-endorphin mediates maternal deprivation effects. Life Sci 48:643-8
Owens, M J; Bartolome, J; Schanberg, S M et al. (1990) Corticotropin-releasing factor concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone. Neuroendocrinology 52:626-31
Kuhn, C M; Pauk, J; Schanberg, S M (1990) Endocrine responses to mother-infant separation in developing rats. Dev Psychobiol 23:395-410
Bartolome, J V; Bartolome, M B; Harris, E B et al. (1989) Regulation of insulin and glucose plasma levels by central nervous system beta-endorphin in preweanling rats. Endocrinology 124:2153-8
Bartolome, J V; Bartolome, M B; Harris, E B et al. (1987) N alpha-acetyl-beta-endorphin stimulates ornithine decarboxylase activity in preweanling rat pups: opioid- and non-opioid-mediated mechanisms. J Pharmacol Exp Ther 240:895-9

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