The Collaborative Depression Study (CDS) has advanced the long-term prospective study of mood disorders. This revised application seeks to extend the prospective annual follow-up of the CDS probands to at least 27 years for all subjects. Renewed funding will permit us to better address the general aim of describing the long-term course of moderate to severe major mood disorders in ways not previously possible and to further investigate the general hypothesis that many individuals with moderate to severe mood disorders will develop a lifelong illness. Since no similar data set exists to collect information of this nature, the next 5 years of continued data collection are essential to gaining a complete perspective of the lifetime course of mood disorders, particularly as many more of our subjects pass the age of 65 when the effects of aging on the course of mood disorders can be better assessed. ? ? The specific aims are to provide long-term, prospective, data that will help investigators to study: (1) the patterns and predictors of course of illness and psychosocial outcome in mood disorders; (2) morbidity, mortality and suicide associated with mood disorders; (3) somatic treatment as a mediating variable of outcome in mood disorders; (4) the longitudinal course of syndromal and sub-syndromal affective symptoms in subjects with unipolar and bipolar depressive disorders; and (5) mood disorders and aging. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH025430-30
Application #
6872156
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (60))
Program Officer
Chavez, Mark
Project Start
1977-07-01
Project End
2009-01-31
Budget Start
2005-02-24
Budget End
2006-01-31
Support Year
30
Fiscal Year
2005
Total Cost
$137,700
Indirect Cost
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Leon, Andrew C; Fiedorowicz, Jess G; Solomon, David A et al. (2014) Risk of suicidal behavior with antidepressants in bipolar and unipolar disorders. J Clin Psychiatry 75:720-7
Cobb, Bryan S; Coryell, William H; Cavanaugh, Joseph et al. (2014) Seasonal variation of depressive symptoms in unipolar major depressive disorder. Compr Psychiatry 55:1891-9
Solomon, David A; Fiedorowicz, Jess G; Leon, Andrew C et al. (2013) Recovery from multiple episodes of bipolar I depression. J Clin Psychiatry 74:e205-11
Akhter, Ahmed; Fiedorowicz, Jess G; Zhang, Tao et al. (2013) Seasonal variation of manic and depressive symptoms in bipolar disorder. Bipolar Disord 15:377-84
Fiedorowicz, Jess G; Endicott, Jean; Solomon, David A et al. (2012) Course of illness following prospectively observed mania or hypomania in individuals presenting with unipolar depression. Bipolar Disord 14:664-71
Persons, Jane E; Coryell, William H; Fiedorowicz, Jess G (2012) Cholesterol fractions, symptom burden, and suicide attempts in mood disorders. Psychiatry Res 200:1088-9
Leon, Andrew C; Solomon, David A; Li, Chunshan et al. (2012) Antiepileptic drugs for bipolar disorder and the risk of suicidal behavior: a 30-year observational study. Am J Psychiatry 169:285-91
Fiedorowicz, Jess G; Coryell, William H; Rice, John P et al. (2012) Vasculopathy related to manic/hypomanic symptom burden and first-generation antipsychotics in a sub-sample from the collaborative depression study. Psychother Psychosom 81:235-43
Fiedorowicz, Jess G; Coryell, William H; Akhter, Ahmed et al. (2012) Chryptochrome 2 variants, chronicity, and seasonality of mood disorders. Psychiatr Genet 22:305-6
Leon, Andrew C; Solomon, David A; Li, Chunshan et al. (2011) Antidepressants and risks of suicide and suicide attempts: a 27-year observational study. J Clin Psychiatry 72:580-6

Showing the most recent 10 out of 44 publications