Abstract

This proposal will address the role of dopamine in psychotic disorders by means of 3 approaches: 1) In rats the uniqueness of prefrontal cortex as a target area for antipsychotic drugs (APD) will be assessed by acute and chronic administration of various APD and measurement of homovanillic acid (HVA) in caudate and prefrontal cortex; 2) in rats prefrontal cortex will also be examined as a possible unique site of action for drugs which can produce psychotic disorders; 3) in patients, plasma HVA and MHPG will be studied with respect to their status as markers for early neuroleptic response in acute psychosis. Promising pilot data has been obtained for each of these areas of study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH028216-11
Application #
3375017
Study Section
(BPNA)
Project Start
1979-05-01
Project End
1988-04-30
Budget Start
1986-05-01
Budget End
1987-04-30
Support Year
11
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Mazure, C M; Quinlan, D M; Bowers Jr, M B (1997) Recent life stressors and biological markers in newly admitted psychotic patients. Biol Psychiatry 41:865-70
Davis, M; Hitchcock, J M; Bowers, M B et al. (1994) Stress-induced activation of prefrontal cortex dopamine turnover: blockade by lesions of the amygdala. Brain Res 664:207-10
Bowers Jr, M B; Mazure, C M; Greenfeld, D G (1994) Elevated plasma monoamine metabolites in eating disorders. Psychiatry Res 52:11-5
Bowers Jr, M B; Morton, J B (1994) Regional brain catecholamines and metabolites following THC, PCP and MK-801. Prog Neuropsychopharmacol Biol Psychiatry 18:961-4
Bowers Jr, M B (1993) Psychotic patients with increased plasma HVA and MHPG or increased HVA alone. Biol Psychiatry 34:584-6
Bowers Jr, M B; Mazure, C M; Nelson, J C et al. (1992) Lithium in combination with perphenazine: effect on plasma monoamine metabolites. Biol Psychiatry 32:1102-7
Mazure, C M; Nelson, J C; Jatlow, P I et al. (1992) Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Res 41:147-54
Bowers Jr, M B; Morton, J B (1992) Diazepam antagonizes effects on dopamine metabolism produced by PCP receptor agonists. Prog Neuropsychopharmacol Biol Psychiatry 16:211-5
Bowers Jr, M B; Hoffman Jr, F J; Morton, J B (1991) Diazepam and haloperidol. Effect on regional brain homovanillic acid levels. Neuropsychopharmacology 5:65-9
Bowers Jr, M B (1991) Characteristics of psychotic inpatients with high or low HVA levels at admission. Am J Psychiatry 148:240-3

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