Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH029591-08
Application #
3375104
Study Section
(BPNA)
Project Start
1977-08-01
Project End
1985-08-31
Budget Start
1984-12-01
Budget End
1985-08-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost
Name
New York University
Department
Type
Schools of Medicine
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
Zhou, G Z; Musacchio, J M (1991) Computer-assisted modeling of multiple dextromethorphan and sigma binding sites in guinea pig brain. Eur J Pharmacol 206:261-9
Klein, M; Canoll, P D; Musacchio, J M (1991) SKF 525-A and cytochrome P-450 ligands inhibit with high affinity the binding of [3H]dextromethorphan and sigma ligands to guinea pig brain. Life Sci 48:543-50
Canoll, P D; Smith, P R; Gottesman, S et al. (1990) Autoradiographic localization of [3H]dextromethorphan (DM) in guinea pig brain: allosteric enhancement by ropizine. Prog Clin Biol Res 328:171-4
Klein, M; Musacchio, J M (1990) Computer-assisted analysis of dextromethorphan and (+)-3-(-3-hydroxyphenyl)-N-(1-propyl)piperidine binding sites in rat brain. Allosteric effects of ropizine. Life Sci 47:1625-34
Musacchio, J M; Klein, M; Canoll, P D (1990) Dextromethorphan sites, sigma receptors, and the psychotomimetic effects of sigma opiates. Prog Clin Biol Res 328:13-6
Klein, M; Zhou, G Z; Paturzo, J J et al. (1990) The effect of sigma ligands on dextromethorphan binding sites in the guinea pig. Prog Clin Biol Res 328:129-32
Canoll, P D; Smith, P R; Musacchio, J M (1990) Ropizine concurrently enhances and inhibits [3H]dextromethorphan binding to different structures of the guinea pig brain: autoradiographic evidence for multiple binding sites. Life Sci 46:PL9-16
Canoll, P D; Smith, P R; Gottesman, S et al. (1989) Autoradiographic localization of [3H]dextromethorphan in guinea pig brain: allosteric enhancement by ropizine. J Neurosci Res 24:311-28
Klein, M; Musacchio, J M (1989) High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents. J Pharmacol Exp Ther 251:207-15
Klein, M; Paturzo, J J; Musacchio, J M (1989) The effect of prototypic sigma ligands on the binding of [3H]dextromethorphan to guinea pig brain. Neurosci Lett 97:175-80

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