The health consequences of bipolar disorder are reflected not only in psychiatric morbidity and mortality associated with recurrent mood episodes, but also in the profound medical burden suffered by these patients. Although collaborative care models for the treatment of depression in primary care have been developed and tested, bipolar disorder is primarily treated in psychiatric settings, meaning that very little attention has been devoted to medical comorbidity in bipolar disorder and no systematic interventions have been developed. This randomized clinical trial of 300 adults with bipolar disorder will compare integrated care treatment with guideline-based psychiatric care only. The integrated care treatment condition consists of three interlocking components: 1) psychopharmacologic management that takes into account specific medical diseases and risk factors common in individuals with bipolar disorder; 2) individualized medical and behavioral management of diseases and risk factors that takes into account each patient's specific psychiatric symptoms and treatment needs; and 3) a lifestyle modification intervention that focuses on risks common to all patients with bipolar I disorder. Our integrated care model will be contrasted to guideline-based psychiatric care only model that follows current evidence-based guidelines for the management of bipolar disorder. Our primary hypotheses are that, compared to guideline-based psychiatric care only, subjects assigned to integrated care treatment will experience: 1) fewer new affective episodes and more days in affective remission and 2) will have better functioning and quality of life. Our secondary hypotheses are that integrated care treatment will result in: 1) higher rates of outpatient medical care and psychiatric care; 2) lower rates of inpatient utilization (both medical and psychiatric) during the 21/2 years of the trial; 3) fewer affective episodes and more days well moderated by baseline medical burden; 4) better functioning and improved quality of life moderated by baseline medical burden; and 5) regular participation in and adherence to lifestyle interventions mediated by sustained remission of mood symptoms. Relevance: Bipolar disorder is a chronic, potentially lethal disease with poor psychiatric outcome that is associated with a high rate of suicide. Medical disease and medical risk factors are common in bipolar disorder and lead to even greater morbidity and mortality. This investigation is directed toward reducing the impact of medical burden on psychiatric outcomes as expressed in levels of functioning, extent of symptomatic remission, and degree of suicidality. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH029618-24A2
Application #
7144574
Study Section
Interventions Research Review Committee (ITV)
Program Officer
Hsiao, John
Project Start
1977-06-01
Project End
2008-07-31
Budget Start
2006-08-01
Budget End
2008-07-31
Support Year
24
Fiscal Year
2006
Total Cost
$262,358
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Brindle, Ryan C; Cribbet, Matthew R; Samuelsson, Laura B et al. (2018) The Relationship Between Childhood Trauma and Poor Sleep Health in Adulthood. Psychosom Med 80:200-207
Brindle, Ryan C; Duggan, Katherine A; Cribbet, Matthew R et al. (2018) Cardiovascular Stress Reactivity and Carotid Intima-Media Thickness: The Buffering Role of Slow-Wave Sleep. Psychosom Med 80:301-306
Hall, Martica H; Mulukutla, Suresh; Kline, Christopher E et al. (2017) Objective Sleep Duration Is Prospectively Associated With Endothelial Health. Sleep 40:
Kline, Christopher E; Krafty, Robert T; Mulukutla, Suresh et al. (2017) Associations of sedentary time and moderate-vigorous physical activity with sleep-disordered breathing and polysomnographic sleep in community-dwelling adults. Sleep Breath 21:427-434
Sylvia, Louisa G; Salcedo, Stephanie; Peters, Amy T et al. (2017) Do Sleep Disturbances Predict or Moderate the Response to Psychotherapy in Bipolar Disorder? J Nerv Ment Dis 205:196-202
Stange, Jonathan P; Sylvia, Louisa G; da Silva Magalhães, Pedro Vieira et al. (2016) Affective instability and the course of bipolar depression: results from the STEP-BD randomised controlled trial of psychosocial treatment. Br J Psychiatry 208:352-8
Levenson, Jessica C; Wallace, Meredith L; Anderson, Barbara P et al. (2015) Social rhythm disrupting events increase the risk of recurrence among individuals with bipolar disorder. Bipolar Disord 17:869-79
Peters, A; Sylvia, L G; Magalhães, P V da Silva et al. (2014) Age at onset, course of illness and response to psychotherapy in bipolar disorder: results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Psychol Med 44:3455-67
Deckersbach, Thilo; Peters, Amy T; Sylvia, Louisa et al. (2014) Do comorbid anxiety disorders moderate the effects of psychotherapy for bipolar disorder? Results from STEP-BD. Am J Psychiatry 171:178-86
Stange, Jonathan P; Sylvia, Louisa G; Magalhães, Pedro Vieira da Silva et al. (2013) Extreme attributions predict transition from depression to mania or hypomania in bipolar disorder. J Psychiatr Res 47:1329-36

Showing the most recent 10 out of 164 publications