Abstract

Factors influencing the development and course of early dyskinesia, of less than a year's duration, are being studied in a sample of 229 neuroleptic-exposed psychiatric patients. Findings in the first cohort of 100 patients show that unipolar depressions are particularly vulnerable to dyskinesia and show the least improvement on three-year followup. These and other findings will be replicated in a second cohort of 100 patients. Twenty-nine dropouts will be used in analyses of factors relating to the onset of dyskinesia. A five-year extension of the study is proposed which will allow data to be obtained on the course of dyskinesia over a 5 to 14 years period. In addition funds are requested to follow a group of over 200 neuroleptic-exposed depressed patients to determine the rate of occurrence of dyskinesia in this population and to study clinical, treatment and biochemical factors which may influence the development of dyskinesia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH032675-11
Application #
3375366
Study Section
Treatment Development and Assessment Research Review Committee (TDA)
Project Start
1979-04-01
Project End
1991-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
11
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Boston Mental Health Foundation
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02178

  Publications

Gardos, G; Casey, D E; Cole, J O et al. (1994) Ten-year outcome of tardive dyskinesia. Am J Psychiatry 151:836-41
Yonkers, K A; Kando, J C; Cole, J O et al. (1992) Gender differences in pharmacokinetics and pharmacodynamics of psychotropic medication. Am J Psychiatry 149:587-95
Cole, J O; Gardos, G; Boling, L A et al. (1992) Early dyskinesia--vulnerability. Psychopharmacology (Berl) 107:503-10
McElroy, S L; Dessain, E C; Pope Jr, H G et al. (1991) Clozapine in the treatment of psychotic mood disorders, schizoaffective disorder, and schizophrenia. J Clin Psychiatry 52:411-4
Gardos, G; Cole, J O; Haskell, D et al. (1988) The natural history of tardive dyskinesia. J Clin Psychopharmacol 8:31S-37S
Gardos, G; Perenyi, A; Cole, J O et al. (1988) Seven-year follow-up of tardive dyskinesia in Hungarian outpatients. Neuropsychopharmacology 1:169-72
Gardos, G; Cole, J O; Schniebolk, S et al. (1987) Comparison of severe and mild tardive dyskinesia: implications for etiology. J Clin Psychiatry 48:359-62
Gardos, G; Cole, J O; Salomon, M et al. (1987) Clinical forms of severe tardive dyskinesia. Am J Psychiatry 144:895-902