The present proposal is a series of studies designed to study clinical and biological correlates of depression in children and adolescents. Specifically, a cohort of children and adolescents meeting criteria for depression and appropriate controls will be identified. The sensitivity, specificity, and diagnostic confidence of dexamethasone suppression tests in the sample will be determined. Family history, particularly of affective disorder, will be compared in the two groups. The relationship between depression and psychosocial factors of experienced life stress, premorbid personality factors, and family environment will be examined. Finally, the course of depression will be followed over a three year period.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH037055-05
Application #
3376011
Study Section
(PCBA)
Project Start
1982-09-28
Project End
1990-05-31
Budget Start
1988-02-01
Budget End
1990-05-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105
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McCauley, E; Carlson, G A; Calderon, R (1991) The role of somatic complaints in the diagnosis of depression in children and adolescents. J Am Acad Child Adolesc Psychiatry 30:631-5
Armsden, G C; McCauley, E; Greenberg, M T et al. (1990) Parent and peer attachment in early adolescent depression. J Abnorm Child Psychol 18:683-97
Mitchell, J; McCauley, E; Burke, P et al. (1989) Psychopathology in parents of depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 28:352-7
McCauley, E; Mitchell, J R; Burke, P et al. (1988) Cognitive attributes of depression in children and adolescents. J Consult Clin Psychol 56:903-8
Mitchell, J; McCauley, E; Burke, P M et al. (1988) Phenomenology of depression in children and adolescents. J Am Acad Child Adolesc Psychiatry 27:12-20
Burke, P M; Reichler, R J; Smith, E et al. (1985) Correlation between serum and salivary cortisol levels in depressed and nondepressed children and adolescents. Am J Psychiatry 142:1065-7