This application concerns the completion of a longitudinal study of psychiatric epidemiology as it relates to data already collected for the period 1952 to 1970 and then extension through the gathering of new data about the period 1970 to 1990. Named the Stirling County Study, the investigation involves multiple cross- sectional surveys and several cohort follow-up studies pertinent to 2848 adult residents of a rapidly changing rural environment in Atlantic Canada. The objectives of the study are to contribute information on trends in prevalence, incidence, outcomes (mortality and morbidity), and treatment of psychiatric disorders in a general population and to relate these variables to risk factors about physical health, life events, and social conditions. The data consist in: 1) self-report of symptoms, impairment, and duration of depression and anxiety disorders through structured questionnaire interviews; 2) reports by general physicians about the full range of psychiatric disorders; 3) a case register of a local mental health center; and 4) death certificates. A diagnostic computer program was written for analyzing information given by subjects. Using this methodology, it was found that during the period from 1952 through 1970 the prevalence of depression and anxiety remained at a stable rate of 12 cases per 100 persons and the incidence of these disorders was, on the average, nine cases per 1000 persons per year. Depression has consistently been distinguished from anxiety, including the fact that depression was found to have significantly worse outcome in terms of both mortality and morbidity. Life table methods, log-linear analysis, and survival regressions are used for calculating rates and testing the significance of associations with risk factors. The application includes research directed toward comparing findings from this investigation with those from other places study, both urban and rural. The degree of concordance between the interview methods of this study and those of more recent studies will be assessed by using the Diagnostic Interview Schedule along with the Stirling Study Schedule in the follow-up interviews to be carried out in 1990.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH039576-04
Application #
3377431
Study Section
Epidemiologic and Services Research Review Committee (EPS)
Project Start
1984-09-30
Project End
1990-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Colman, Ian; Kingsbury, Mila; Sucha, Ewa et al. (2018) Depressive and anxious symptoms and 20-year mortality: Evidence from the Stirling County study. Depress Anxiety 35:638-647
Gilman, Stephen E; Sucha, Ewa; Kingsbury, Mila et al. (2017) Depression and mortality in a longitudinal study: 1952-2011. CMAJ 189:E1304-E1310
Murphy, Jane M; Gilman, Stephen E; Lesage, Alain et al. (2010) Time trends in mortality associated with depression: findings from the Stirling County study. Can J Psychiatry 55:776-83
Murphy, J M; Leighton, A H (2009) Anxiety: its role in the history of psychiatric epidemiology. Psychol Med 39:1055-64
Murphy, J M; Horton, N J; Burke Jr, J D et al. (2009) Obesity and weight gain in relation to depression: findings from the Stirling County Study. Int J Obes (Lond) 33:335-41
Murphy, Jane M; Burke Jr, Jack D; Monson, Richard R et al. (2008) Mortality associated with depression: a forty-year perspective from the Stirling County Study. Soc Psychiatry Psychiatr Epidemiol 43:594-601
Litman, Heather J; Horton, Nicholas J; Murphy, Jane M et al. (2006) Marginal regression models with a time to event outcome and discrete multiple source predictors. Lifetime Data Anal 12:249-65
Murphy, J M; Horton, N J; Laird, N M et al. (2004) Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution, and comorbidity. Acta Psychiatr Scand 109:355-75
Bassuk, Shari S; Murphy, Jane M (2003) Characteristics of the Modified Mini-Mental State Exam among elderly persons. J Clin Epidemiol 56:622-8
Murphy, Jane M; Horton, Nicholas J; Monson, Richard R et al. (2003) Cigarette smoking in relation to depression: historical trends from the Stirling County Study. Am J Psychiatry 160:1663-9

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