Abstract

The proposed research is designed to extend previous observations indicating that immune processes are subject to behavioral conditioning. Using an illness-induced taste aversion paradigm, rats and/or mice are conditioned by pairing a distinctively flavored drinking solution (the conditioned stimulus) with immunopharmacologic agents that may suppress or enhance immunologic reactivity (the unconditioned stimulus). After conditioning, all animals are treated with antigen (e.g., sheep erythrocytes). Antibody titers or cellular immune responses (delayed type hypersensitivity reactions) are measured after immunogenic stimulation in conditioned animals that are reexposed to the conditioned stimulus, conditioned animals that are not reexposed to the conditioned stimulus, conditioned animals injected with the immunopharmacologic agent, and in nonconditioned and placebo-treated groups. Current studies are directed to defining those parameters of the conditioning process and those parameters of antigenic stimulation and the immune response that may be optimal for the conditioning of immunopharmacologic effects and to an examination of the immune processes that can be modulated by conditioning.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH042051-12
Application #
3381048
Study Section
Neurology C Study Section (NEUC)
Project Start
1986-04-01
Project End
1989-06-30
Budget Start
1988-04-01
Budget End
1989-06-30
Support Year
12
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
School of Medicine & Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Moynihan, J A; Ader, R (1996) Psychoneuroimmunology: animal models of disease. Psychosom Med 58:546-58
Moynihan, J A; Karp, J D; Cohen, N et al. (1994) Alterations in interleukin-4 and antibody production following pheromone exposure: role of glucocorticoids. J Neuroimmunol 54:51-8
Tuttle, R S; Moynihan, J A; Grota, L J et al. (1994) CO2 anesthesia facilitates a serum antibody response to orally-administered antigens. Life Sci 55:879-84
Karp, J D; Cohen, N; Moynihan, J A (1994) Quantitative differences in interleukin-2 and interleukin-4 production by antigen-stimulated splenocytes from individually- and group-housed mice. Life Sci 55:789-95
Ader, R; Kelly, K; Moynihan, J A et al. (1993) Conditioned enhancement of antibody production using antigen as the unconditioned stimulus. Brain Behav Immun 7:334-43
Cocke, R; Moynihan, J A; Cohen, N et al. (1993) Exposure to conspecific alarm chemosignals alters immune responses in BALB/c mice. Brain Behav Immun 7:36-46
Kusnecov, A V; Grota, L J; Schmidt, S G et al. (1992) Decreased herpes simplex viral immunity and enhanced pathogenesis following stressor administration in mice. J Neuroimmunol 38:129-37
Kusnecov, A W; Cohen, N; Moynihan, J (1992) Adjuvant effects of freely ingested cholera toxin on systemic antibody and DTH responses to protein antigen. Reg Immunol 4:153-61
Ader, R; Cohen, N (1992) Conditioned immunopharmacologic effects on cell-mediated immunity. Int J Immunopharmacol 14:323-7
Moynihan, J A; Brenner, G J; Ader, R et al. (1992) The effects of handling adult mice on immunologically relevant processes. Ann N Y Acad Sci 650:262-7

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