The proposed research is designed to extend previous observations indicating that immune processes are subject to behavioral conditioning. Using an illness-induced taste aversion paradigm, rats and/or mice are conditioned by pairing a distinctively flavored drinking solution (the conditioned stimulus) with immunopharmacologic agents that may suppress or enhance immunologic reactivity (the unconditioned stimulus). After conditioning, all animals are treated with antigen (e.g., sheep erythrocytes). Antibody titers or cellular immune responses (delayed type hypersensitivity reactions) are measured after immunogenic stimulation in conditioned animals that are reexposed to the conditioned stimulus, conditioned animals that are not reexposed to the conditioned stimulus, conditioned animals injected with the immunopharmacologic agent, and in nonconditioned and placebo-treated groups. Current studies are directed to defining those parameters of the conditioning process and those parameters of antigenic stimulation and the immune response that may be optimal for the conditioning of immunopharmacologic effects and to an examination of the immune processes that can be modulated by conditioning.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project (R01)
Project #
Application #
Study Section
Neurology C Study Section (NEUC)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Rochester
School of Medicine & Dentistry
United States
Zip Code
Moynihan, J A; Ader, R (1996) Psychoneuroimmunology: animal models of disease. Psychosom Med 58:546-58
Moynihan, J A; Karp, J D; Cohen, N et al. (1994) Alterations in interleukin-4 and antibody production following pheromone exposure: role of glucocorticoids. J Neuroimmunol 54:51-8
Tuttle, R S; Moynihan, J A; Grota, L J et al. (1994) CO2 anesthesia facilitates a serum antibody response to orally-administered antigens. Life Sci 55:879-84
Karp, J D; Cohen, N; Moynihan, J A (1994) Quantitative differences in interleukin-2 and interleukin-4 production by antigen-stimulated splenocytes from individually- and group-housed mice. Life Sci 55:789-95
Ader, R; Kelly, K; Moynihan, J A et al. (1993) Conditioned enhancement of antibody production using antigen as the unconditioned stimulus. Brain Behav Immun 7:334-43
Cocke, R; Moynihan, J A; Cohen, N et al. (1993) Exposure to conspecific alarm chemosignals alters immune responses in BALB/c mice. Brain Behav Immun 7:36-46
Kusnecov, A V; Grota, L J; Schmidt, S G et al. (1992) Decreased herpes simplex viral immunity and enhanced pathogenesis following stressor administration in mice. J Neuroimmunol 38:129-37
Kusnecov, A W; Cohen, N; Moynihan, J (1992) Adjuvant effects of freely ingested cholera toxin on systemic antibody and DTH responses to protein antigen. Reg Immunol 4:153-61
Ader, R; Cohen, N (1992) Conditioned immunopharmacologic effects on cell-mediated immunity. Int J Immunopharmacol 14:323-7
Moynihan, J A; Brenner, G J; Ader, R et al. (1992) The effects of handling adult mice on immunologically relevant processes. Ann N Y Acad Sci 650:262-7

Showing the most recent 10 out of 15 publications