The importance of physiologic, metabolic, and endocrine studies for the understanding of anorexia nervosa (AN) remains a disputed subject. Recent reports on neuroendocrine changes in vasopressin (AVP) and norepinephrine (NE), CT scans, cognitive processing, and physical features (e.g., hypothermia) identified prolonged dysfunctions in weight-recovered anorectics. The majority of these reports are almost exclusively descriptive and no integrated biologic theory has been proposed to explain these putative """"""""slowly-reversible"""""""" phenomena and their role in the pathogenesis and maintenance of AN. In this grant we will assess the hypothesis that """"""""residual"""""""" biologic abnormalities resulting from starvation/cold-acclimatization processes and nausea/malaise-induced processes leading to conditioned food avoidance may perpetuate entrenched stereotyped behaviors and quasi-delusional thinking. The main residual biological variables that will be studied are: 1) cold-acclimatization induced thermoregulatory alterations such as nonshivering thermogenesis related to brown adipose tissue, and change in diurnal regulation; 2) marked fluctuations in skin and core temperatures and thermogenic hormones in response to ambient cold challenges (e.g., cold pressor test, climatic chamber); 3) postprandial effects of a caloric stimulus related to thermic changes, psychological state, and gastrointestinal discomfort; 4) NMR-detected enlarged cerebral sulci and ventricles related to basal hormone changes, and possibly, to cognitive performance; and 5) gradual return of metabolic function, body temperature, diurnal cycles and the menstrual cycle. We will characterize these weight-dependent changes that occur in our AN population at two different periods: 1) early in their treatment at admission (greater than 20% below IBW) and 2) following recovery of weight loss to within 5% IBW. Weight-dependent changes in thermoregulation (e.g., hypothermia) and cognitive processing (e.g., cognitive neuromotor tasks) will be assessed biweekly. Experimental perturbations are designed to characterize the relation of plasma ACTH, cortisol, AVP, NE and E to specific """"""""persisting"""""""" features, e.g., temperature fluctuations, vomiting).

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH042210-01
Application #
3381323
Study Section
(PCBB)
Project Start
1987-02-01
Project End
1990-01-31
Budget Start
1987-02-01
Budget End
1988-01-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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Doraiswamy, P M; Figiel, G S; Husain, M M et al. (1991) Aging of the human corpus callosum: magnetic resonance imaging in normal volunteers. J Neuropsychiatry Clin Neurosci 3:392-7
Doraiswamy, P M; Krishnan, K R; Boyko, O B et al. (1991) Pituitary abnormalities in eating disorders: further evidence from MRI studies. Prog Neuropsychopharmacol Biol Psychiatry 15:351-6
Shah, S A; Doraiswamy, P M; Husain, M M et al. (1991) Assessment of posterior fossa structures with midsagittal MRI: the effects of age. Neurobiol Aging 12:371-4
Escalona, P R; McDonald, W M; Doraiswamy, P M et al. (1991) In vivo stereological assessment of human cerebellar volume: effects of gender and age. AJNR Am J Neuroradiol 12:927-9
Hoffman, G W; Ellinwood Jr, E H; Rockwell, W J et al. (1990) Brain T1 measured by magnetic resonance imaging in bulimia. Biol Psychiatry 27:116-9
Doraiswamy, P M; Krishnan, K R; Figiel, G S et al. (1990) A brain magnetic resonance imaging study of pituitary gland morphology in anorexia nervosa and bulimia. Biol Psychiatry 28:110-6
Lurie, S N; Doraiswamy, P M; Husain, M M et al. (1990) In vivo assessment of pituitary gland volume with magnetic resonance imaging: the effect of age. J Clin Endocrinol Metab 71:505-8
Hoffman Jr, G W; Ellinwood Jr, E H; Rockwell, W J et al. (1989) Cerebral atrophy in anorexia nervosa: a pilot study. Biol Psychiatry 26:321-4

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