Abstract

Although family, twin, and adoption studies indicate that heredity plays a role in manic-depression (MDI) and schizophrenia, the genetic factors involved or their mode of inheritance remains unknown. Important advances in molecular biology over the past decade now make it possible to determine the approximate chromosomal location of the gene(s) that may play a role in these illnesses. Toward this goal, identifying multigenerational families afflicted with MDI and schizophrenia is crucial. We have identified several such families and are searching for others. Permanent cell lines are being established and DNA processed for restriction endonuclease mapping. As a result of this project, the etiology, genetics, and treatment of MDI and schizophrenia may be better understood.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH042643-01A1
Application #
3381875
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1988-06-01
Project End
1991-05-31
Budget Start
1988-06-01
Budget End
1989-05-31
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Segurado, Ricardo; Detera-Wadleigh, Sevilla D; Levinson, Douglas F et al. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. Am J Hum Genet 73:49-62
Lewis, Cathryn M; Levinson, Douglas F; Wise, Lesley H et al. (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am J Hum Genet 73:34-48
Myles-Worsley, M; Coon, H; McDowell, J et al. (1999) Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. Am J Med Genet 88:544-50
Adler, L E; Olincy, A; Waldo, M et al. (1998) Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull 24:189-202
Fang, N; Coon, H; Hoff, M et al. (1995) Search for a schizophrenia susceptibility gene on chromosome 18. Psychiatr Genet 5:31-5
Coon, H; Sobell, J; Heston, L et al. (1994) Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia. Am J Med Genet 54:12-20
Coon, H; Holik, J; Hoff, M et al. (1994) Analysis of chromosome 22 markers in nine schizophrenia pedigrees. Am J Med Genet 54:72-9
Coon, H; Jensen, S; Holik, J et al. (1994) Genomic scan for genes predisposing to schizophrenia. Am J Med Genet 54:59-71
Freedman, R; Adler, L E; Bickford, P et al. (1994) Schizophrenia and nicotinic receptors. Harv Rev Psychiatry 2:179-92
Byerley, W; Hoff, M; Holik, J et al. (1993) VNTR polymorphism for the human dopamine transporter gene (DAT1). Hum Mol Genet 2:335

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