The object of this proposal is to locate and then characterize DNA sequences associated with Alzheimer's Disease (AD) or Pick's Disease (PD) or both. Six families, five at high risk for AD and one for PD, have been followed by us for ten to twelve years as part of a clinical genetic study of dementing illness. They will be the basis for this study. An additional four high risk families, less well known to us, will be further investigated and included in this study if they are willing and suitable. We propose to establish lymphoblastic cell lines on all living relatives. We will then search for linkage between DNA fragments and known markers first on chomosome 21 but then at other locations depending on our progress and developments in the related sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH043240-02
Application #
3382610
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1987-12-01
Project End
1992-11-30
Budget Start
1989-02-01
Budget End
1989-11-30
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
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Schellenberg, G D; Bird, T D; Wijsman, E M et al. (1992) Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258:668-71
Heston, L L; Orr, H T; Rich, S S et al. (1991) Linkage of an Alzheimer disease susceptibility locus to markers on human chromosome 21. Am J Med Genet 40:449-53