This competing continuation is part of a 2-site collaborative research grant with an identical application submitted concurrently by Dr. Lauren B. Alloy at Temple University. Prior research did not provide an adequate test of the hopelessness theory (HT) and Beck's theory (BT) of depression and may have been misleading about those cognitive theories' validity. Thus, the overarching goal of this project is to provide a more powerful test of HT's and BT's predictions about the etiology of depression and a validation of the Hopelessness Depression subtype. To this end, a large scale, 5.5-year prospective study was conducted at both sites. Initially nondepressed, non-psychopathological Ss (n=349) who were at either high or low cognitive risk for depression were followed prospectively with independent and blind self-report and interview assessments of stressful life events, cognitions, social support, coping, and psychiatric status/symptoms in order to predict onsets and subsequent recurrences of depression. Familial and developmental origins of cognitive vulnerability to depression also were examined, including assessment of the parents (n=335) of high-risk and low-risk Ss. In this renewal, differential predictors of first onsets vs. recurrences of depression, factors that increase resilience among high-risk Ss and promote depression among low-risk Ss, factors that contribute to and moderate change in cognitive vulnerability, and different models of cognitive vulnerability-stress relations also were investigated. This project contributes to: 1) the scientific understanding of the etiology and course of a subset of the mood disorders; 2) a more valid nosologv of the depressive disorders; 3) an understanding of the origins and continuity/change of cognitive vulnerability to depression; 4) an understanding of factors that promote resilience to depression; and 5) the development of interventions for treating and preventing depression.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH043866-10
Application #
6435738
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (01))
Program Officer
Dolan-Sewell, Regina
Project Start
1990-08-01
Project End
2003-12-31
Budget Start
2002-02-11
Budget End
2002-12-31
Support Year
10
Fiscal Year
2002
Total Cost
$180,177
Indirect Cost
Name
University of Wisconsin Madison
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Shapero, Benjamin G; Black, Shimrit K; Liu, Richard T et al. (2014) Stressful life events and depression symptoms: the effect of childhood emotional abuse on stress reactivity. J Clin Psychol 70:209-23
Cain, A S; Bardone-Cone, A M; Abramson, L Y et al. (2010) Prospectively predicting dietary restraint: the role of interpersonal self-efficacy, weight/shape self-efficacy, and interpersonal stress. Int J Eat Disord 43:505-12
Iacoviello, Brian M; Alloy, Lauren B; Abramson, Lyn Y et al. (2010) The early course of depression: a longitudinal investigation of prodromal symptoms and their relation to the symptomatic course of depressive episodes. J Abnorm Psychol 119:459-67
Safford, Scott M; Alloy, Lauren B; Abramson, Lyn Y et al. (2007) Negative cognitive style as a predictor of negative life events in depression-prone individuals: a test of the stress generation hypothesis. J Affect Disord 99:147-54
Showers, C J; Abramson, L Y; Hogan, M E (1998) The dynamic self: how the content and structure of the self-concept change with mood. J Pers Soc Psychol 75:478-93