This is the second phase of a three-phase prospective longitudinal study of 250 6- through 10-year-old disruptive and/or depressive boys. The general aims of the study are: to extend a two-factor model of child disruptive psychopathology to a third factor of depression or emotionality; to externally validate that extended three-factor model, using convergently and divergently valid direct measures of the three factors (i.e., inattention-overactivity, aggression, and emotionality); to compare the extended three-factor model to several stages of the DSM and Achenbach assessment models; to improve understanding of comorbidity within and between the disruptive and depressive disorders; to develop and test methods for combining, assessment data from different instruments and informants into sound diagnostic decisions; and to make a consolidated empirically-derived proposal for subgrouping the disruptive and depressive disorders/dimensions. Considered categorically, there are eight subgroups of referred boys: (1) exclusively hyperactive = H; (2) exclusively aggressive = A; (3) exclusively emotional = E; (4) combined hyperactive and aggressive = HA; (5) combined hyperactive and emotional = HE; (6) combined aggressive and emotional = AE; (7) mixed hyperactive and aggressive and emotional = HAE; and (8) neither hyperactive nor aggressive nor emotional = psychiatric controls or PC, as well as 200 classmate comparison boys or CC, and 80 full brothers. The dependent criteria for external validation include: symptom expression variables (e.g., duration, severity, and pervasiveness); impairment variables (academic problems, friendships, treatments); family context variables (e.g., family composition, parenting styles, marital harmony); cognitive and laboratory measures (e.g., intellectual functioning, academic skills, CPT); observational measures (e.g., behavior in play and task settings, parent-child interactions); generation indices (i.e., child and adult dimensions and disorders in parents); course of symptoms (psychiatric symptoms/behavioral dimensions assessed at average ages of 8, 12, and 15); and diagnostic outcomes (assessment and prediction of psychiatric disorders/ behavioral dimensions at age 15). This second phase of the investigation will complete follow-up of 250 probands between ages 11 and 13; and it will incorporate a sibling comparison component, using information about the 6- through 10-year-old and the 11-through 13-year-old sisters and brothers of the referred boys to answer more fully questions about the expression, diagnosis, and development of disruptive and depressive dimensions/disorders in boys and girls.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH044733-07
Application #
2698768
Study Section
Special Emphasis Panel (ZMH1-CRB-H (01))
Program Officer
Nottelmann, Editha
Project Start
1992-04-01
Project End
2000-05-31
Budget Start
1998-09-15
Budget End
1999-05-31
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Drabick, Deborah A G; Gadow, Kenneth D; Loney, Jan (2008) Co-occurring ODD and GAD symptom groups: source-specific syndromes and cross-informant comorbidity. J Clin Child Adolesc Psychol 37:314-26
Drabick, Deborah A G; Gadow, Kenneth D; Loney, Jan (2007) Source-specific oppositional defiant disorder: comorbidity and risk factors in referred elementary schoolboys. J Am Acad Child Adolesc Psychiatry 46:92-101
Loney, Jan; Carlson, Gabrielle A; Salisbury, Helen et al. (2005) Validation of three dimensions of childhood psychopathology in young clinic-referred boys. J Atten Disord 8:169-81
Gadow, Kenneth D; Drabick, Deborah A G; Loney, Jan et al. (2004) Comparison of ADHD symptom subtypes as source-specific syndromes. J Child Psychol Psychiatry 45:1135-49
Sprafkin, Joyce; Gadow, Kenneth D; Salisbury, Helen et al. (2002) Further evidence of reliability and validity of the Child Symptom Inventory-4: parent checklist in clinically referred boys. J Clin Child Adolesc Psychol 31:513-24
Pierre, C B; Nolan, E E; Gadow, K D et al. (1999) Comparison of internalizing and externalizing symptoms in children with attention-deficit hyperactivity disorder with and without comorbid tic disorder. J Dev Behav Pediatr 20:170-6
Carlson, G A; Loney, J; Salisbury, H et al. (1998) Young referred boys with DICA-P manic symptoms vs. two comparison groups. J Affect Disord 51:113-21